ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 25–32
Gershtein E.S., Kuzmin Yu.B., Alferov A.A., Korotkova E.A., Tsarapaev P.V., Sokolov N.Yu., Kuznetsov I.N., Vashketova O.I., Kozlova E.M., Yanushevich O.O., Boulytcheva I.V., Stilidi I.S., Kushlinskii N.E.
Background. Low sensitivity of bone tumors to various schemes of standard chemotherapy stimulated the search of new targets for their medicamentous treatment. Among such targets are the so-called “immune checkpoints” promoting the escape of the tumor from the …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Kushlinskii N. E., Gershtein E. S., Timofeev Yu. S., Korotkova E. A., Babkina I.V., Zuev A.A., Soloviev Yu.N.
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…