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MOLECULAR MECHANISMS OF NEUROINFLAMMATION AND SLEEP DEPRIVATION IN THE DEVELOPMENT OF AGE-ASSOCIATED COGNITIVE DYSFUNCTION

Nazarova K.E., Kostromina R.A., Malinovskaya N.A., Khilazheva E.D., Komleva Y.K.

Introduction. Proinflammatory cytokines produced in elevated concentrations in the elderly significantly impair neurogenesis in the dentate gyrus of the hippocampus, long-term potentiality, alter neuronal morphology and function, and increase apoptosis. This l…