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MOLECULAR GENETIC CHARACTERISTICS OF NON-SMALL CELL LUNG CANCER USING MULTI-TARGET SINGLE-BASE ELONGATION AND FRAGMENT ANALYSIS

Musaelyan A.A., Nazarov V.D., Lapin S.V., Chistyakov I.V., Komarov I.V., Tkachenko O.U., Sogoyan M.V., Berdnik E.W., Mazing A.V., Emanuel W.L., Akopov A.L., Orlov S.V., Bagnenko S.F.

Background. Lung cancer is the most frequent cause of cancer mortality. The prevailing type is non-small cell lung cancer (NSCLC), in the treatment of which EGFR tyrosine kinase inhibitors are actively used, as well as a combination of BRAF and MEK inhibitors.…

FABOMOTIZOLE AS MEANS OF PHARMACOLOGICAL CORRECTION OF PRE- AND POSTNATAL DISTURBANCES INDUCED BY PEAT SMOKE POLLUTION, TOBACCO SMOKE, ALCOHOL, HYPERGLYCEMIA AND CYCLOPHOPHAMIDE IN THE DEVELOPMENT OF OFFSPRING OF RATS

Solomina A.S., Shreder O.V., Mokrova E.D., Zabrodina V.V., Gorbatova D.M., Kolik L.G, Durnev A.D.

Introduction. Influence of environmental hazards on pregnant women or development of pregnancy in presence of pathogenic pathway may lead to miscarriage, teratogenic effects and/or significant abnormalities in physical development, cognitive and behavioral sta…

CLINICAL SIGNIFICANCE OF GENE CYP2C19 POLYMORPHISM IN STEMI PATIENTS (DATA FROM THE KEMEROVO REGISTRY OF THE ACUTE CORONARY SYNDROME)

Kochergina A.M., Kashtalap V.V., Gordeeva L.A., Kochergin N.A., Barbarash O.L.

Aim is to evaluate distribution and clinical significance of gene CYP2C19 polymorfism in ST-segment elevation myocardial infarction (STEMI) patients. Materials and methods. A total of 159 patients were encluded in this study. All of them underwent primary PCI.…

PREDICTION THE RISK OF ISCHEMIC STROKE ON THE BASE ON GENETIC [APOE (Ε2, Ε3, Ε4), ACE (I / D), MTHFR (677S> T)] AND NON-GENETIC FACTORS WITH THE USE OF MODERN METHODS OF THE THEORY OF RECOGNITION BY PRECEDENTS

Nazarenko G.I., Zhuravlev Yu.I., Ryazanov V.V., Konstantinova M.V., Kleymenova E.B.

Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…

APPLICATION OF PHARMACOGENETICS TESTING IN PATIENTS WITH CARDIAC VALVE REPLACEMENT

Goncharova I.A., Golubenko M.V., Gorbunova E.V., Salakhov R.R., Markov А.А., Zhuravleva I.Yu., Маkееvа О.А., Puzyrev V.P.

Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…

MOLECULAR GENETIC MARKERS OF NON-SMALL CELL LUNG CANCER

Mazurenko N.N., Kushlinskii N.E.

Lung cancer is one of the most common oncologic diseases in the world and the most frequent cause of the death from malignant neoplasms. Last decade’s studies revealed significant number of molecular events leading to the onset and development of non-small cel…

THE RISK ASSESSMENT OF DEVELOPMENT OF CHOROIDAL NEOVASCULARIZATIONIN AGE-RELATED MACULAR DEGENERATION

Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…

POLYMORPHYSMS OF XENOBIOTICS BIOTRANSFORMATION AND CELL PROLIFERATION CONTROL GENESAND THEIR ASSOCIATION WITH RISK OF CANCER OF RESPIRATORY TRACT IN POPULATION OF MOSCOW REGION

Atkarskaya M.V., Zavarykina T.M., Zhizhina G.P., Burlakova E.B.

The associations of polymorphic markers of the xenobiotics – metabolizing genes (GSTТI, GSTМI, GSTPI), cell cycle regulation genes (ТР53,CDKNI) and of the gene XRCCI repairing damaged DNA bases in 54 healthy subjects and 50 patients with upper respiratory trac…