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PD-1 PATH: BIOLOGICAL SIGNIFICANCE, CLINICAL APPLICATION, AND EXISTING PROBLEMS

Kushlinskii N.E., Fridman M.V., Morozov A.A., Chertkova A.I., Gershtein E.S., Kadagidze Z.G.

The review is devoted to the studies of immune check-point (programmed death) molecules – PD-1 receptor and its ligands PD-L1 and PD-L2, which play an important role in the regulation of immune response. Special attention is paid to soluble (s) forms of PD-1 a…