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Molecular Medicine
Found: 29
The purpose of this review is to discuss the role of serotonin in the processes of neurogenesis in the hippocampus in post-traumatic stress disorder. Full-text materials were searched in Medline (PubMed) and Scopus databases over the past 15 years. Results. Co…
The results of experimental replacement of the bladder wall up to subtotal using multicomponent tissue-engineered structures are presented. Purpose. Development and experimental use of a tissue-engineered structure for replacing various volumes of the bladder …
Introduction. The use of mesenchymal stem cells (MSCs) is recognized as a promising direction for the treatment of diseases with a predominance of inflammation and sclerosis in the pathogenesis, which includes nephrotuberculosis (NT). Target. Studying the effe…
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
The purpose of the study was to analyze literature data on the use of mesenchymal stem cells as a conservative treatment of osteoarthritis. Material and methods. Literature search was carried out using keywords: traumatology, orthopedics, mesenchymal stem cell…
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell th…
The aim of this work is to study the effect of the AED peptide on fibroblast differentiation of human skin when aging in vitro. Methods. The study was conducted on DF-1 cell line (human dermal fibroblasts (mesenchymal stem cells)) isolated from the skin of the…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Introduction. Degenerative retinal diseases are considered as the leading cause of blindness and low vision worldwide. The last studies have provided convincing evidence of the involvement of immunological factors in the development and progression of the dise…
Neurodegenerative diseases are a group of pathologies of the nervous system, which are characterized by progressive death of nerve cells and gradually increasing atrophy of the corresponding parts of the brain or spinal cord. In developed countries, an increas…
The review considers the system of hyaluronic acid (HA), represented by its receptors, the enzymes of synthesis (hyaluronan synthase), cleavage (hyaluronidase). The participation of the HA system in the regulation of the cell cycle was demonstrated. The most i…
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Cancer stem cells (CSCs), which are less sensitive to chemotherapeutic drugs than other tumor cells, play a key role in the initiation and development of the tumor process. Maintenance of CSCs determines the risk of cancer recurrence. The aim of …
Introduction. The brain injury induced during radiotherapy and chemotherapy is largely dependent on a disruption of neurogenesis in the subgranular zone of the dentate gyrus in the hippocampus as a result of the neural stem cells (NSCs) damage. The aim of the …
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
A half century of studying the neurogenesis of the adult brain has produced much evidence for an endogenous conversion of neural stem cells. Yet the idea receives increasing criticism, in addition to the many positive comments. Does neurogenesis proceed at a r…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…