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TNF GENE POLYMORPHISMS AFFECT THE PROGRESSION OF THE DISEASE IN BREAST CANCER PATIENTS

Alferova E.V., Malivanova T.F., Kononenko I.B., Vergun A.A., Kutuzova N.M., Manzyuk L.V., Mazurenko N.N.

Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…