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MOLECULAR MECHANISMS OF RESISTANCE DEVELOPMENT UNDER TARGETED THERAPY ON THE EXAMPLE OF CUTANEOUS MELANOMA

Ruksha T.G., Zemtsov D.S., Lavrentiev S.N., Palkina N.V., Yessimbekova A.R.

Cutaneous melanoma is a highly heterogeneous malignancy, which characterized by low effectiveness of chemotherapeutic antitumor agents. 50% of melanomas have a somatic mutation in BRAF oncogene, leading to uncontrolled activation of mitogen-activated protein k…