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FUNDAMENTALS AND PROBLEMS OF SUICIDE GENE ANTITUMOR THERAPY

Nemtsova E.R., Bezborodova O.A., Yakubovskaya R.I., Kaprin A.D.

The review of the literature on suicide gene therapy is presented. The therapeutic method is based on the transfection of tumor cells with a construct including the gene of the enzyme converting the substrate – the prodrug demonstrating low toxicity into a hig…