Аннотация
Целью настоящего обзора являлось описание сведений об этиологии и патогенезе основных проявлений у пациентов с коронавирусной инфекцией COVID-19 и молекулярных механизмов возможного применения метаболитных препаратов. Материал и методы. Поиск полнотекстовых материалов производился в базах данных Medline (Pubmed) и Scopus за последние 15 лет. Результаты. По результатам анализа источников подробно описаны механизмы нарушений микроциркуляции, возможные пути проникновения вируса в центральную нервную систему и его влияние на клетки мозга. Поражение нейронов и нарушение их нормального функционирования может приводить к долгосрочным последствиям инфекции. Использование метаболитов для коррекции состояния клетки может естественным путем способствовать снижению воспаления за счет различных молекулярных механизмов. Заключение. Доказанное цитопротективное и иммуномодулирующее действие глицина обусловливает его возможное применение в терапии COVID-19. Использование антиоксидантов, таких как глутатион, патогенетически обосновано для коррекции эндотелиальной дисфункции и гипоксии нейронов.
Ключевые слова
Авторы и аффилиации
Е.В. Машковцева, Я.Р. Нарциссов Научно-исследовательский институт цитохимии и молекулярной фармакологии, Российская Федерация, 115404, Москва, ул. 6-я Радиальная, д. 24, стр. 14 Е-mail: yarosl@biotic.dol.ru
Литература
Сайт Всемирной организации здравоохранения www.who.int. [Website of the World Health Organization www.who.int (in Russian)]
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