Аннотация
Цель: анализ данных литературы по HPgV-инфекции, вызываемой вирусом Human pegivirus-1 (ранее гепатит G, HGV, GBV-C). Материал и методы: поиск, по ключевым словам, публикаций в базах данных Scopus, PubMed и Elibrary за период с 1995 по 2020 г. Результаты: описана история изучения вируса, его строение, генетическая гетрогенность, а также проблема эпидемиологии, тропизма и патогенеза данной инфекции. В связи с наличием ряда свойств вируса отражены возможные перспективы исследования HPgV-инфекции для популяционной генетики и генной терапии. Представлены современные данные о связи HPgV-инфекции с ВИЧ-инфекцией, лимфомами и некоторыми другими заболеваниями. Дана краткая характеристика относительно недавно описанного вируса 2-го типа (HPgV-2). Обозначены проблемы диагностики и интерпретации HPgV-инфекции в Российской Федерации и зарубежных странах. Заключение: несмотря на то, что изначально возбудитель HPgV-инфекции был описан как причина развития гепатита, он не является цитопатическим вирусом, а заражение не связано с развитием патологических процессов.
Авторы и аффилиации
В.В. Литвинов(1), Г.Г. Фрейнд(1), В.П. Коробов(2), А.Д. Шестакова(3) 1-ФГБОУ ВО «Пермский государственный медицинский университет им. академика Е.А. Вагнера» Минздрава России, Российская Федерация, 614000, Пермь, ул. Петропавловская, д. 26; 2-ФГБУН Пермского федерального исследовательского центра «Институт экологии и генетики микроорганизмов УрО РАН», Российская Федерация, 614081, Пермь, ул. Голева, д. 13; 3-ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова», Российская Федерация, 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, д. 68 E-mail: drlitvinov@mail.ru
Литература
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