DBH GENE POLYMORPHISM IN PSORIASIS PATIENTS

Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatry, there is formed a new scientific field called psychodermatology, which highlights the nature of the link between skin diseases and mental disorders. The aim of the study is to evaluate the role of 3 polymorphic loci in the dopamine beta-hydroxylase (DBH) gene (rs141116007, rs2097629, and rs1611115) in the development of psoriasis. Methods. Genotypes were studied with PCR-RFLP method. Restriction products were separated in 2% agarose gene. Statistical analysis was performed in WinPepi and in APSampler software. Results. We discovered an association of rs1611115:T allele with psoriasis. This allele has a recessive model of inheritance – the presence of C allele reduces risk of psoriasis by 4 times. Complex genotype study revealed an association between rs1611115:TT genotype with psoriasis: p<0,001, OR=3,88. No significant associations were found between rs141116007 and rs2097629. Conclusion. Associated with psoriasis genotype rs1611115:TT is related to decreased DBH activity, increased dopamine concentration and decreased norepinephrine concentration. We suggest altered concentrations of these neuromediators to play a role in the development of psoriasis.

L.R. Sakaniya(1), A.V. Tretiakov(2), A.A. Shevtsova(2, 3), Z.G. Kokaeva(2), O.I. Rudko(2), A.G. Soboleva(1), I.M. Korsunskaya(1), E.A. Klimov(2, 3, 4), V.V. Sobolev(1, 4, 5) 1-Centre of Theoretical Problems of Physico-Chemical Pharmacology, Kosygina st. 4, Moscow, 119991, Russian Federation; 2-Lomonosov Moscow State University, Leninskie Gory, 1–12, Moscow, 119234, Russian Federation; 3-Center of Experimental Embryology and Reproductive Biotechnologies, Kostyakova str., 12–4, Moscow, 127422, Russian Federation; 4-University Diagnostic Laboratory, Shestidesyatiletia Oktyabrya prospect, 18–3, Moscow, 117036, Russian Federation; 5-I.I. Mechnikov Research Institute for Vaccines and Sera, Malyi Kazenny bystreet, 5, Moscow, 105064, Russian Federation E-mail: vlsobolew@gmail.com