PROVOCATION OF OXIDATIVE STRESS BY HEAVY METALS AS A POSSIBLE TRIGGER FACTOR IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS

Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges.
Material and methods. A review of the literature on the molecular mechanisms of the effects of heavy metals on the body.
Results. It is known that ecotoxicants provoke various nonspecific processes in the body, including oxidative stress (OS). The latter, in turn, according to a fairly large number of studies, is represented in rheumatoid, and possibly plays a pathogenetic role in this disease. The aim of the review is to analyze the mechanisms of the possible role of heavy metals in the development of rheumatoid arthritis. The review presents an analysis of publications by Russian and foreign authors over the past 10 years. Since environmental factors are modifiable to a certain extent, the study of specific mechanisms of the triggering effect of these factors on individuals at risk is of great practical importance.
Conclusion. The influence of the certain environmental factors, including heavy metals, as well as various combinations of these factors, on the development of rheumatoid arthritis in individuals at risk requires further study.

E.A. Takha(1), E.A. Shuralev(2), Y. Renaudineau(3), M.I. Arleevskaya(1, 2)
1-Kazan State Medical Academy – a branch of the Federal State Budgetary Educational Institution of Additional Professional
Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation,
36 Butlerova St., Kazan, 420012, Russian Federation;
2-Federal State Autonomous Educational Institution of Higher Education «Kazan (Volga Region) Federal University»,
18 Kremlyovskaya St., Kazan, 420008, Russian Federation;
3-Laboratory of immunology, chu purpan, inserm1291/cnrs5051, University Paul Sabatier, Toulouse, France