Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
«RISKY» COMBINATIONS OF CANDIDATE GENES FOR HYPERPLASTIC PROCESSES OF THE ENDOMETRIUM
Introduction. Endometrial hyperplasia represents a chronic progressive disease characterized by high prevalence among women in older age groups. The aim of the study. To study the involvement of combinations of candidate genes in the formation of hyperplastic …
LOSS OF HETEROZYGOSITY ON CHROMOSOMES 1, 3 AND 8 IN UVEAL MELANOMA PATIENTS
Introduction. Uveal melanoma (UM) is the most common primary intraocular tumor in adults. This type of cancer is characterized by the high metastatic activity in the liver, which is the crucial factor for 95% of patients’ bad outcome in any case of the treatme…
THE STUDY OF MECHANISMS OF THE ACTION OF METILIN IN MYOCARDIAL ISCHEMIA/REPERFUSION INJURY
The aim of the study. This study was designed to explore relationships between the activation of signaling pathways triggered by a novel cardioprotective drug Metilin, on one hand, and the recovery of metabolic state and the membrane stability in cardiomyocyte…
ANGIOTROPIC EFFECTS OF DIPEPTIDE MIMETICS OF THE NERVE GROWTH FACTOR LOOP 4
Aim. The study of the angiotropic activity of dipeptide mimetics of the nerve growth factor (NGF) loop 4 possessing properties of TrkA receptor agonists and antagonists. Methods. Experiments in vitro. Angiotropic effects of dipeptide mimetics of the NGF loop 4…
THE CYP2C19*2, CYP2C19*3 POLYMORPHISMS ASSOCIATED WITH THE RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SINDROME IN THE YAKUT AND RUSSIAN ETHNIC GROUPS
ntroduction. The aim of this study was to determine the prevalence rate of CYP2C19 alleles, associated with the risk of the resistance to clopidogrel and the development of thrombotic complications in patients with acute coronary syndrome (ACS) from Russian an…
ПЕРЕДОВАЯ СТАТЬЯ
PHARMACOLOGICAL TREATMENT OF PARKINSON’S DISEASE: MOLECULAR ASPECTS AND PROSPECTS
Parkinson’s disease (PD) is a progressive, age-related, neuronal disorder that affects as much as 1% of the persons over 65 years. According to forecasts of the World Health Organization over the world about 9 million people will suffer from PD by 2030. So PD …
ОБЗОРЫ
COMPARATIVE CLINICAL-PHARMACOLOGICAL ANALYSIS OF THE EFFICIENCY AND SAFETY OF INHIBITORS OF SGLT CO-TRANSPORTERS
Diabetes mellitus (DM) is a dangerous challenge to the entire international community and the priority of the first order national health systems of all countries over the world. The growing level of hyperglycemia in type 2 diabetes is associated with the incr…
GENETICS OF PRIMARY HEADACHES (LITERATURE REVIEW)
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
GENETIC PREDICTORS OF ISONIASID HEPATOTOXICITY
Currently, tuberculosis is the second leading cause of death from an infectious agent in the world and an important social and medical-biological problem. The first-line drug isoniazid is one of the most effective antituberculosisdrug, however it has a wide sp…