Table of contents
ОБЗОРЫ
PROSTATE-SPECIFIC MEMBRANE ANTIGEN: MODERN POSSIBILITIES IN THE DIAGNOSIS OF PROSTATE CANCER
Diagnosis and determination of tumor process in patients with prostate cancer are the most urgent problems of modern оncology. Prostate-specific membrane antigen (PSMA) is one of the most promising molecular targets for the diagnosis of prostate cancer. The le…
MECHANISM OF THE DAMAGING ACTION OF DEXTRAN SODIUM SULPHATE AT THE MODEL OF ACUTE COLITIS IN MICE
The use of dextran sodium sulphate (DSS) as an agent for the induction of the experimental colitis is regarded as a valid method in experimental biology and medicine for the estimation of the effectiveness of pharmacological preparations for the treatment of i…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE LEVEL OF NITRIC OXIDE METABOLITES AND NOS2 GENE TRANSCRIPTS IN RHEUMATOID ARTHRITIS
The aim of this work was to study the effect of methotrexate, glucocorticoids and nonsteroidal anti-inflammatory drugs on the plasma levels of nitric oxide metabolites, as well as the level of NOS2 gene transcripts in peripheral blood leukocytes (PBL) in rheum…
PROGNOSTIC SIGNIFICANCE EXPRESSION OF MRNA TOP1, TOP2Α, TUBΒ3, TYMS, ABCC5 AND GSTP1 GENES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER
Introduction. Despite the continuous improvement of the surgical method of treatment of patients with non-small cell lung cancer (NSCLC), there is no noticeable tendency to improve survival data. This 5-year index does not exceed 15–25%. In this regard, it is …
THE STUDY OF HOMEOSTATIC MECHANISMS OF THE MAINTENANCEOF THE LEVEL OF ENDOGENOUS CALCIUM FOR THE COMPARATIVE EVALUATION OF ABSORPTION OF CALCIUM FROM THE GASTROINTESTINAL TRACT
Purpose. To study pharmacokinetic parameters in studies of a comparative bioavailability in combination with the assessment of homeostatic mechanisms of the regulation on the example of calcium. Methods. There were studied pharmacokinetic parameters of calcium…
THE PREVALENCE OF CYP2C19*2, *3 POLYMORPHISMS AMONG RUSSIANS AND YAKUTS WITH PEPTIC ULCER DISEASE, LIVING IN SAKHA REPUBLIC (YAKUTIA)
Introduction. Proton pump inhibitors (PPI) are widely spread as antisecretory drugs for a treatment of acid diseases, such as the gastric ulcer. Most of the proton pump inhibitors are inactivated in the liver by cytochromes P450 2C19 (CYP2C19) to the form of i…
THE STUDY OF TOXICOLOGICAL PROPERTIES OF THE POLYMERIC FORM OF AN ETOPOSIDE
Introduction. The clinical use of the antitumor drug etoposide is associated with many side effects, limiting its application in the clinical practice. One of the ways to reduce the toxicity and increase the effectiveness of the action of etoposide can be its …
DETERMINATION OF TELOMERASE ACTIVITY BY REAL TIME DOUBLE TELOMERIC REPEAT AMPLIFICATION PROTOCOL
Introduction.The telomerase activity is a universal marker for 85% of malignant tumors. This allows us to develop modern highly sensitive and highly specific kits for the diagnosis of most malignant tumors, including early stages of the disease. Existing metho…
PHARMACOGENETIC TESTING BY POLYMORPHIC MARKERS G1846A (CYP2D6*4) AND C100T (CYP2D6*10) CYP2D6 GENE IN CORONARY HEART DISEASEPATIENTS, TAKING BETA-BLOCKERS IN THE SAKHA REPUBLIC (YAKUTIA)
Introduction. The aim of this study to determine carrier frequencies of polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between theadmin…
MACROPHAGAL ADSORPTION OF MULTIPOTENT MESENCHYMAL STROMAL CELLS AND THEIR DEBRIS FROM VASCULAR BED PROVES THE MIGRATION OF THESE CELLULAR ELEMENTS THROUGH THE VESSELS AFTER TISSUE INJECTION
Introduction. The use of cell technologies has particular effectiveness in the treatment of many diseases. However, the literature contains data concerning macrophages ability of a phagocytosis and lysisofautologic multipotent mesenchymal stromal cells of a bo…
EVALUATION OF THE ROLE OF POLYMORPHIC VARIANTS OF NO-SYNTHASES GENES OF IN PATHOGENESIS OF PSORIASIS
The aim of the study was to analyze two single nucleotide substitutions in the NOS2 (rs2779249, c-1290G>T, 5'-region) and NOS3 (rs2070744, c-813C>T, in tron 1) genes in psoriasis patients. Materials and methods. DNA samples from 88 psoriasis patients and 365 c…