Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Α-SYNUCLEIN AND AΒ42 PEPTIDE EXPRESSION IN SUBSTANTIA NIGRA AND BUCCAL EPITHELIUM IN PARKINSON DISEASE PATIENTS OF THE DIFFERENT AGE
Introduction. The current direction of modern medicine is the development of new methods for non-invasive diagnosis of neurodegenerative diseases, in particular, Parkinson's disease. The goal of the investigation was the comparative analysis of α-synuclein and…
PROTECTION OF NEURAL STEM CELLS FROM GENOTOXIC EFFECTS BY FACTORS SECRETED BY MESENCHYMAL STEM CELLS
Introduction. The brain injury induced during radiotherapy and chemotherapy is largely dependent on a disruption of neurogenesis in the subgranular zone of the dentate gyrus in the hippocampus as a result of the neural stem cells (NSCs) damage. The aim of the …
INVESTIGATIONS OF THE 125I-LABELLED TARGET MOLECULES DARPIN9_29 FOR RADIONUCLIDE DIAGNOSTICS OF MALIGNANT TUMORS WITH HER2/NEU OVEREXPRESSION
Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…
MORPHOLOGICAL CHANGES IN THE COLON AND COMPOSITION OF PERIPHERAL BLOOD LYMPHOCYTES IN ACUTE COLITIS IN MICE WITH DIFFERENT RESISTANCE TO HYPOXIA
Introduction. According to literature, there is individual and linear variability of severity of acute ulcerative colitis induced by dextran sodium sulfate in mice. The resistance to hypoxia could be one of the possible mechanisms underlying the individual dif…
ASSOCIATION OF GENETIC MARKERS WITH THE DEVELOPMENT OF ENDOCARDITIS OF NONINFECTIOUS AND INFECTIOUS ETIOLOGY
Introduction. New technologies of DNA genotyping and sequencing contribute to the rapid accumulation of our knowledge about human genomic variations and search for inherited determinants of complex genetic traits. There is a large amount of data on association…
MOLECULAR MORPHOLOGY OF THE VAGINAL WALL WITH THE INCONSISTENCY OF THE PELVIC FLOOR
Introduction. Prolapse of pelvic organs being extremely common in the female population, hence, it is important to search for factors of prolapse pathogenesis to identify markers of the optimal time for surgical intervention. The aim of the study is to investi…
MOLECULAR GENETIC ASPECTS OF THE RISK FOR FAMILY ADENOMATOUS POLYPOSIS
Introduction. The origin of the genetic predisposition to family adenomatous polyposis is associated with functional disorders of the repair system. The molecular mechanism of this phenomenon is not sufficiently studied and need clarification. The aim of the s…
ОБЗОРЫ
SIMULATION OF SPINAL CORD REGENERATION IN VITRO SYSTEM
Among the injuries of the central nervous system, a special place is occupied by injuries of the spinal cord (SC), which are still practically resistant to treatment and cause severe consequences. Necrosis of the tissue – the immediate consequence of the mecha…
MELATONIN AND CIRCADIAN RHYTHMS IN THE SYSTEM «MOTHER-PLACENTA-FETUS»
The review summarizes a number of the published reports about the structure of the core circadian oscillator system and the melatonin’s role as an interface of endogenous rhythms for the cyclic environment what optimizes maternal, placental and fetal physiolog…
FUNDAMENTALS AND PROBLEMS OF SUICIDE GENE ANTITUMOR THERAPY
The review of the literature on suicide gene therapy is presented. The therapeutic method is based on the transfection of tumor cells with a construct including the gene of the enzyme converting the substrate – the prodrug demonstrating low toxicity into a hig…
PHARMACOGENETIC ASPECTS OF THE EFFICACY AND SAFETY OF LEUKOTRIENE MODIFIERS IN BRONCHIAL ASTHMA THERAPY
The efficacy of bronchial asthma therapy is one of the most urgent problems in allergology and pulmonology. The efficacy of leukotrienes modifiers in bronchial asthma therapy is not achieved in 35–78% cases. In addition, there are data on unwanted drug reactio…