Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
MOLECULAR MECHANISMS OF RETARDATION OF SKIN AGING UNDER INFLUENCE 0F HUMAN PLACENTA HYDROLYSATE
Introduction. Application of placenta hydrolysate in cosmetology opens a new page in anti-aging therapy. Numerous studies have confirmed the antioxidant, anti-inflammatory, anti-pigmental properties of placenta hydrolysate preparations, as well as activation o…
THE SOME PECULIARITIES OF CAPSULAR FORMATION AFTER IMPLANTATION OF SILICONE WITH ADSORBED MULTIPOTENT MESENCHYMAL STROMAL CELLS
Introduction. The widespread cellular technologies will sooner or later lead inevitably to the introduction of multipotent mesenchymal stromal cells (MMSC) or their exosomes to patients who have implanted artificial materials in their organism. The engraftment…
STUDY OF EXPRESSION OF MMP-1 GENE IN LOCALIZED SСLERODERMIA
The aim of the study was to investigate the expression of the MMP-1 gene in patients with a diagnosis of localized scleroderma. Methods. The study included 12 patients with an established diagnosis of localized scleroderma. The material of the study consisted …
ACTIVATING POINT MUTATION OF BRCA1/2 GENES IN AZERBAIJAN POPULATION
Introduction. Breast cancer is the leading cancer type among woman of Azerbaijan population. Hereditary mutations of the BRCA1/2 genes are considered as high risk for appeared breast and ovarian cancers. In Azerbaijan BRCA1/2-related breast and ovarian cancer …
OPTIMIZATION OF THE METHOD OF THE MULTI-TARGET SINGLE-BASE ELONGATION FOR THE DETECTION OF SOMATIC MUTATIONS IN MALIGNANCIES
Background. Genotyping of the tumor samples is necessary for a personalized approach in the treatment of patients with malignancies. The identification of somatic mutations in EGFR and KRAS genes can help to predict the course of the disease and to individuali…
ОБЗОРЫ
EPIGENETIC REGULATION OF REVERSE CHOLESTEROL TRANSPORT: THE ROLE OF MICRO-RNAS
Micro-RNAs are a group of small non-coding RNA molecules regulating target genes at the post-transcriptional level. Micro-RNAs are involved in the control of many pathophysiological processes, including dyslipidemia, the main risk factor for atherosclerosis. C…
MOLECULAR PATHOGENESIS AND MARKERS FOR RENAL CELL CARCINOMA
The review highlights current data on molecular pathogenesis and potential markers of clear cell renal cell carcinoma, obtained in MultiOmyx studies. Key molecular mechanisms of the pathogenesis of RCC are the loss of functions of the VHL, PBRM1, SETD2, BAP1, …
MOLECULAR AND EPIGENETIC FACTORS IN THE SCHIZOPHRENIA DEVELOPMENT
Schizophrenia is a severe psychiatric disorder with etiology not clearly determined yet. Scientists associate its development with various factors including excessive expression of some genes and unstable social environment. The World Health Organization estim…