Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
RELATIONSHIP BETWEEN OXIDATIVE PROTEIN MODIFICATION AND THE ACTIVITY OF LYSOSOMAL CYSTEINE PROTEINASES IN BLOOD PLASMA AND LEUKOCYTES IN ALZHEIMER’S DISEASE
Introduction. Revealing the relationship between the severity of oxidative stress and the activity of cathepsins in tissues (plasma and blood cells) readily available for the diagnosis of Alzheimer’s disease can be useful for understanding the pathogenesis of …
A MODEL OF SURFACE PLASMON RESONANCE IMMUNOSENSOR FOR DETERMINING AUTOANTIBODIES TO GLUTATHIONE-S-TRANSFERASE IN SERUM SAMPLES
Introduction. The quantitative determination and isotyping of autoantibodies to a clinically significant protein – glutathione-S-transferase (GST) in blood serum samples is relevant for monitoring and predicting the dynamics of autoimmune processes. The aim of…
PROTECTIVE EFFECT OF BIOREGULATORY PEPTIDES ON THE ORGANOTYPIC TISSUE CULTURE DEVELOPMENT IN CYTOSTATIC PRESENCE
Introduction. The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of heal…
STANDARDIZATION OF THE METHOD OF MULTI-TARGET SINGLE-NUCLEOTIDE ELONGATION FOR MOLECULAR GENETIC STUDY OF CYTOLOGICAL MATERIAL IN THYROID NEOPLASM
Introduction. Thyroid cancer (TC) is the most prevalent cancer among malignant neoplasms of the organs of the endocrine system. Cytological categories Bethesda III–V of TC are considered to be the most difficult for making a diagnosis. Molecular genetic tests …
EXPRESSION OF FACTORS ACTIVATED BY HYPOXIA, GROWTH FACTOR VEGF, ITS RECEPTOR, CARBOHYDRASE IX IN TISSUE IN PAPILLARY CANCERs AND METASTASES
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
ОБЗОРЫ
MOLECULAR MECHANISMS OF RESISTANCE DEVELOPMENT UNDER TARGETED THERAPY ON THE EXAMPLE OF CUTANEOUS MELANOMA
Cutaneous melanoma is a highly heterogeneous malignancy, which characterized by low effectiveness of chemotherapeutic antitumor agents. 50% of melanomas have a somatic mutation in BRAF oncogene, leading to uncontrolled activation of mitogen-activated protein k…
MOLECULAR AND GENETIC MECHANISMS OF INFLAMMATORY BOWEL DISEASES AND THEIR BIOCHEMICAL MARKERS
Ulcerative colitis and Crohn’s disease represent one of the most pressing problems of modern medicine. Even though much attention paid to the development and implementation of high-tech diagnostic methods, inflammatory bowel diseases (IBD) tend to increase in …
FEATURES OF IRON EXCHANGE IN PATIENTS WITH LUNG TUBERCULOSIS (REVIEW OF LITERATURE)
Iron is an essential trace element not only for the human body, but also for some microorganisms, including mycobacterium tuberculosis. Being strict aerobes, mycobacteria receive iron from the human body using the siderophore transporter system. Iron deficienc…
ПЕРЕДОВАЯ СТАТЬЯ
THE PRINCIPLES OF PREDICTIVE GENETIC TESTING AND SCREENING IN THE CONCEPT OF PERSONALIZED MEDICINE
The review discusses the principles of predictive genetic testing and screening in the concept of personalized medicine. The criteria for screening developed by WHO in 1968, as well as modern supplemented and refined criteria for genetic testing for multifacto…