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Molecular Medicine
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
The use of haloperidol in clinical practice is often accompanied by the development of severe unwanted adverse side effects from the side of various organs and systems. In the narcological practice the use of antipsychotic drugs is not seldom complicated by ex…
Early endothelialization of the inner surface of cardiovascular grafts is imperative for achieving successful functioning in the body. Biofunctionalization of synthetic materials allows to create biomimetic surfaces by incorporating bioactive molecules capable…
In this brief review there are considered possible reasons for the spread of disease of the multifactorial nature in modern populations from standpoints of the discordance between evolutionary formed genetic diversity and rapidly changing environmental factors…
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
Staphylococcus aureus – the pathogenic microorganism that can cause as well hospital as community-acquired diseases. The emergence and subsequent spread of strains resistant to many antimicrobial agents, and, above all, methicillin-hospital strains (HA-MRSA) a…
On the basis of published data there were assessed criteria of eligibility of paraffin blocks with malignant tumors for the decision of a question of the genetic identity of the samples. In order to prevent potential errors it’s not recommended to use the carc…
Retinal vascular occlusion is one of the most severe vascular lesions of the eye, leading to permanent disability. Approximately 16 million adults in the world have this pathology at the age over 40 years. Typically, the disease occurs acutely as a result of m…
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…