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Molecular Medicine
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …
The computational study of 3D-model hyaluronidase interaction with shortchain glycosaminoglycan ligands had performed demonstrating the diversity and significance of their reaction on enzyme structure. The purpose of this review was evolution of limiting enzym…
Гепатоцеллюлярная карцинома (ГЦК) является наиболее распространенной первичной злокачественной опухолью печени. Специфичность иммунной микросреды органа ограничивает возможности традиционных терапевтических и хирургических подходов к лечению, поэтому одной из …
Сердечно-сосудистые заболевания (ССЗ) являются основной причиной заболеваемости и смертности. Важной задачей кардиологии является поиск и изучение новых биомаркеров. Интерес ученых активно сосредоточен на изучении интерлейкина (IL)-11. Целью обзора литературы …
Введение. Сепсис – это полиорганная дисфункция в ответ на генерализацию инфекционного процесса. Вероятность развития сепсиса коррелирует с значением биохимических параметров, которые могут служить прогностическими маркерами. Эндотелий, как структурная основа с…
Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as t…
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
Introduction. Recurrent pregnancy loss (RPL) is an early spontaneous termination of pregnancy before 20 weeks, which is defined as two or more miscarriages. Most of the known causes associated with the pathophysiology of RPL include endocrine disorders, antiph…