SIGNALING MOLECULES IN BUCCAL EPITHELIUM: OPTIMIZATION OF DIAGNOSIS OF SOCIALLY SIGNIFICANT DISEASES

Buccal epithelium (BE) is an easily accessible target for molecular diagnosis of various diseases, and non-invasive way to get it is
possible. This review summarizes the results of studies indicating a change in the expression of various signaling molecules and electrokinetic
characteristics of BE in pathological processes, and evaluation of a biological age of human beings. Found that the BE has been established
to be informative material in the diagnosis of a number of socially significant diseases, including immune pathology, bronchial asthma,
ulcerative colitis, Crohn's disease, tumor growth and metabolic disorders.

M.A. Paltsev (1), I.M. Kvetnoy (2), V.O. Polyakova (2), S.S. Konovalov (3), O.M. Litvyakova (3), N.S. Linkova (3), N.N. Sevostyanova (3), A.O. Durnova (2), G.Kh. Tolibova (2)
1 -National Research Centre «Kurchatov Institute»
2 -Federal State Budgetary Institution «The Research Institute of Obstetrics and Gynecology named after D.O. Ott» of the North-West Branch of the Russian Academy of Medical Sciences
3 -Saint-Petersburg Institute of Bioregulation and Gerontology of the North-West Branch of the Russian cademy of Medical Sciences