Abstract
The paper presents the results of our own investigation of abnormal methylation of tumor suppressor genes RASSF1A, P16, CDH1,
LAMC3, DAPK in tumors and non-tumor tissues obtained from 64 patients with superficial bladder cancer. The purpose of the research is
to determine the participation of adjacent non-tumor tissue in the «field cancerization» in the genesis of urothelial carcinomas. We present
experimental evidence and analysis of the literature, confirming the possibility of urothelial carcinoma arising to the formation of the «field
cancerization», which is the consistent complex of the tumor and non-tumor tissue.
Keywords
Authors and affiliations
A.Yu. Babayan (1), D.V. Zaletaev (1,2), M.V. Nemtsova (1,2)
1 -State Budgetary Educational Institution of Higher Professional Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Health care and Social Development, Moscow, Russian Federation,
2 -Federal State Budgetary Institution «Research Centre of Medical Genetics» of the Russian Academy of Medical Sciences, Moscow, Russian Federation