Abstract
Associations between matrix metalloproteinase (MMP) 2, 7, 9, tissue MMP inhibitor TIMP-1 and plasminogen activation system
components (uPA, tPA and PAI-1) plasma and/or tumor levels in colorectal cancer (CRC) patients were evaluated in order to reveal their
potential clinical implications. Two groups of CRC patients monitored for 5 or 10 years were enclosed in the study. Earlier, corresponding
markers’ levels were measured in their plasma and/or tumors by immunoenzymatic techniques. High tumor PAI-1 (≥4,0 ng/mg protein)
was demonstrated to be a significant, but not independent unfavorable prognostic factor for 5 and 10 years overall survival. Its role was
mostly pronounced in stage III patients. High preoperative plasma MMP-7 and TIMP-1 levels (cut-offs – 4,0 and 347 ng/ml respectively)
were shown to be independent unfavorable prognostic factors, and univariate analysis revealed unfavorable prognostic value of high tumor
MMP-7 content (≥7,8 ng/mg protein) in patients with disseminated process.
Keywords
Authors and affiliations
E.S. Gershtein, E.A. Korotkova, V.V. Prorokov, N.E. Kushlinskii
Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian Federation