Table of contents
Articles
MARKERS OF ENDOMETRIAL RECEPTIVITY FOR IMPLANTATION: THE ROLE AND THE VALUE IN IN-VITRO FERTILIZATION CYCLES
Implantation is the key process for becoming pregnant. Failure of implantation in IVF cycles is one of the main problems of modern reproductology. Search for biomarkers and the determination of the best time and maximal endometrial receptivity for the implemen…
INTERLEUKIN-15: THE STRUCTURE, SIGNALING AND ROLE IN THE IMMUNE PROTECTION
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
MOLECULAR GENETIC MECHANISMS OF THE DEVELOPMENT OF THE CROHN’S DISEASE
In the literature review there are presented the modern views on the concept of the pathogenesis of Crohn’s disease (CD). There has been analyzed the role of defects in innate immunity in CD associated with mutations in genes NOD2/CARD15, ATG16L1, IRGM which r…
SEARCH FOR ANTAGONISTS OF NR3C4 RECEPTOR
Introduction. One of the main types of a hormonal therapy in the treatment of the cancer of the prostate gland is the antagonists of the NR3C4 (nuclear receptor subfamily 3, group C, member 4) receptor. It blocks binding of man’s hormones with receptors site, …
ELEVATION OF SERUM LEVELS OF SOLUBLE FORMS OF STRESS-INDUCED MOLECULES MICA IN ONCOLOGICAL DISEASES
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
THE PROBLEMS OF RETT SYNDROME DIAGNOSIS IN GIRLS WITHOUT A MUTATION IN THE MEСP2 GENE: APPLICATION OF MOLECULAR KARYOTYPING
Introduction. Rett syndrome (RTT) is the most common genetic syndrome underlying mental retardation and autism in girls. Etiology of this disorder is related to mutation in the MECP2 gene. However, there are many cases of this disease without the MECP2 mutatio…
THE MYH7, MYBPC3 GENE MUTATIONS IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS RESIDING IN THE REPUBLIC OF BELARUS
Introduction. Hypertrophic cardiomyopathy (HCM) is a common genetically heterogeneous disease caused by mutations in genes encoding proteins of the cardiac sarcomere. Mutations in the genes encoding β-myosin heavy chain (MYH7) and myosin binding protein C (MYB…
THE ASSOCIATION OF PROTEASOME ACTIVITY AND SUBUNITS COMPOSITION WITH ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION IN BREAST АND ENDOMETRIAL CANCERS
Introduction. The features of pathogenesis of main tumors of the female reproductive system are determined by the impact of estrogen on target tissues. In this connection there appears the need to study the regulation of estrogen and progesterone receptors in …
THE LEVEL OF SOME TUMOR MARKERS IN THE SKIN MELANOMA TISSUE, ITS PERIFOCAL AREA AND ALONG THE RESECTION LINE
Introduction. In spite of active research, no highly specific and sensitive marker of skin melanoma has been found so far. The aim of the study. Studying the level of stem cell factor (SCF), neuron-specific enolase (NSE), sCD44std, and heat shock proteins Hsp2…
COMT GENE POLYMORPHISM AND RADIATION REACTIONS OF NORMAL TISSUE IN BREAST CANCER PATIENTS
Introduction. The COMT gene encodes for a protein involved in deactivation of genotoxic estrogen species, and the protein product encoded by the L (low activity) allele is 3–5-fold less active than its counterpart encoded by the H (high activity) allele. The a…