Table of contents
Articles
C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGENE – PROGNOSTIC FACTOR OF SKELETAL METASTASES IN BREAST CANCER PATIENTS
Introduction. Skeletal involvement is a frequent and troublesome complication of breast malignant tumors. The accurate diagnosis of bone metastasis and well-timed prescription of the antiresorptive therapy are essential for reducing both severity and mortality…
RESEARCH OF ANTINEOPLASTIC ACTIVITY OF CHIMERIC PEPTIDE P16_ANTP IN VIVO
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
INTERLEUKIN 16 IN THE SERUM BONE
Introduction. Progress in the treatment of cancer and bone tumors including, is associated with a significant breakthrough in molecular biology, immunology, understanding the causes of the emergence of the tumor cell, patterns of the development and course of …
TYMS GENE POLYMORPHISMS IN PATIENTS WITH GASTRIC CANCER, THE RELATIONSHIP WITH LONG-TERM RESULTS OF COMBINED TREATMENT
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
INSULIN-LIKE GROWTH FACTORS (IGF) AND IGF BINDING PROTEINS IN BLOOD SERUM AND TUMORS OF OVARIAN TUMOR PATIENTS
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…
MOLECULAR GENETIC MARKERS OF NON-SMALL CELL LUNG CANCER
Lung cancer is one of the most common oncologic diseases in the world and the most frequent cause of the death from malignant neoplasms. Last decade’s studies revealed significant number of molecular events leading to the onset and development of non-small cel…
BIOLOGICAL ASPECTS OF MYOMETRIAL HYPERPLASIA: THE POSSIBLE ROLE OF CLINICALLY SIGNIFICANT GENE VARIANTS
The aim of our review article was to analyze different biological effects associated with functional allelic variants of certain genes upon the incidence and clinical course of uterine leiomyoma (UL) and some other hyperplastic uterine disorders. Based on a nu…
INCREASE IN THE MALIGNANT PROPERTIES OF HUMAN PANCREATIC DUCTAL ADENOCARCINOMA CELLS DUE TO REPRESSION OF HNF4α NUCLEAR RECEPTOR SYNTHESIS
Introduction. Pancreatic ductal adenocarcinoma (PDAC) is notable for its high aggressiveness and low efficiency of diagnostic and treatment approaches. Nuclear receptor HNF4α is one of the possible regulators of the development and differentiation of pancreati…
THE PHOSPHORYLATED AKT1 KINASE, VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS: INTRATUMORAL CONTENT AND PROGNOSTIC SIGNIFICANCE IN BREAST CANCER PATIENTS
Introduction. PI3K/Akt signaling pathway is an important intracellular regulatory mechanism controlling cues of growth factors stimuli, apoptosis, proliferation, and cell motility. Deregulation of activity/expression of PI3K/Akt signaling pathway proteins dete…
SEVERAL GENETIC FEATURES OF HUMAN METASTATIC CUTANEOUS MELANOMA
Introduction. The prevalence of human cutaneous melanoma (CM) in the world is constantly rising. Diagnostics and treatment of CM at the early stages allows to increase the 5-year patient survival up to 90%. This problem can be solved with personalized therapy …