Table of contents
Articles
ENDOMETRIUM: FROM NUCLEAR RECEPTORS TO TEST MODELS OF NEW DRUGS
Introduction. Endocrine factors are considered to be important in the etiology of spontaneous abortion. Aim of the study. Histological and immunohistochemical characterization of the expression of estrogen and progesterone receptors in the gravid endometrium d…
M.A. Paltsev is 65 years of age
HUMAN BRAIN DEVELOPMENT BEFORE BIRTH: INFLUENCE OF CHEMICALS AND SEXUAL DIFFERENTIATION
Addictive substances, medication, and environmental substances can permanently disrupt fetal brain development, which might ultimately lead to learning difficulties as well as to many types of behavioral disorders in later life. Congenital defects of this kind…
ASSOCIATION OF KISSPEPTINS WITH TUMOROGENESIS IN THE FEMALE REPRODUCTIVE SYSTEM
Introduction. Kisspeptins (KP) are family of peptide mediators regulating function of gonadotrophic axis through the control of secretion of gonadotrophins at the central level. Also was shown that they are synthesized in other tissues and organs, where they h…
IMMUNOHISTOCHEMICAL CRITERIA FOR ENDOMETRIAL RECEPTIVITY DURING IMPLANTATION WINDOW
Introduction. The one of the important ways of increasing the effectiveness of the methods of IVF is to study the mechanisms of regulation of implantation. Implantation is a multicomponent and strictly specific system, any violation of it leads to a deteriorat…
FEATURES OF EXPRESSION OF SEX STEROID HORMONES RECEPTORS IN PELVIC ENDOMETRIOSIS
Introduction. Changes of steroid hormone receptors take an important place in the pathogenesis of endoemtriosis. Literature data about estrogen receptor-alpha (ERα) in this disease is contradictory. The aim of our study was to determine the expression of ERα a…
APPLICATION OF NGS METHOD FOR ACVR2A GENE SEQUENCING IN WOMEN WITH PREECLAMPSIA
Introduction. Preeclampsia is one of the most frequent complications of pregnancy. Disease is based on the pathology of the vascular system of a pregnant woman. One of the candidate genes of preeclampsia is a gene encoding a protein receptor type 2A to activin…
DEVELOPMENT AND EVALUATION OF A DIAGNOSTIC MICROCHIP PANEL FOR THE DETECTION OF AGENTS OF UROGENITAL INFECTIONS
Introduction. Development of rapid and accurate tests is of priority in microbiological diagnostics, including diagnostics of urogenital infections. The aim of the study. The study aimed to develop and evaluate a diagnostic microchip panel based on real-time P…
DYNAMICS OF EXPRESSION SIGNALING MOLECULES IN PATIENTS OF OLDER AGE GROUPS UNDER THE INFLUENCE OF LOW-INTENSITY MILLIMETER WAVES
Introduction. In recent years among non-drug methods of treatment and rehabilitation of patients of elderly and senile age is a promising application of low-intensity millimeter waves as an important reserve of increasing the effectiveness of the complex thera…
THE IMPACT OF PROSTAGLANDIN F2α ANALOGUE AND UROKINASE PLASMINOGEN ACTIVATOR ON PRIMARY RETINAL PIGMENT
Introduction. Modulation of cellular adhesion of the retinal pigment epithelium (RPE) is a highly promising therapeutic approach for different eye diseases. As inflammation plays the crucial role in ocular diseases the impact of prostaglandins and proteases on…
MORPHOFUNCTIONAL AND CYTOCHEMICAL CHARACTERISTICS OF ERYTHROCYTES IN FRAILTY PATIENTS
Introduction. Currently, the study of molecular and cellular bases for the development of frailty is an actual scientific problem. The aim of the article is to study the morphofunctional and cytochemical characteristics of erythrocytes in frailty patients. Met…
INHIBITION OF STEROIDOGENESIS REDUCES STRUCTURAL RADIATION-INDUCED DAMAGES OF ENDOCRINE CELLS
Introduction. Neuroendocrine cells are involved in multiple regulatory processes. In the article the attention is paid to the key signaling molecules that provide local interactions between neuroendocrine cells after radiation exposure. The aim of the study. T…