Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
CLINICAL SIGNIFICANCE OF BIOLOGICAL OPTIONS OF BREAST CANCER
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
CLINICAL AND MOLECULAR ASPECTS OF GASTRIC CANCEROGENESIS
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
MOLECULAR MARKERS AS A DIAGNOSTIC TOOL AND PROGNOSTIC FACTOR IN BONE TUMOR PATHOLOGY
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
MOLECULAR-BIOLOGICAL MARKERS IN THE DIAGNOSIS OF THE NEUROENDOCRINE TUMORS
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
THE BIOCHEMICAL MARKERS OF NEUROENDOCRINE TUMORS: ANALYTICAL AND CLINICAL ASPECTS
The lecture considers common concepts of neuroendocrine tumors (NETs). Unlike the other tumors, NETs synthesize a variety of biologically active substances (hormones, peptides, amines), that being their main feature with multiple consequences leads to the deve…
SOME TISSUE MARKERS AND MULTIGENE SIGNATURES OF BREAST CANCER: PROGNOSIS AND DETERMINATION OF DRUG SENSITIVITY
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
MICRORNAS IN ONCOLOGICAL DISEASES
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
MOLECULAR BIOLOGICAL CHARACTERISTICS OF MALIGNANT TUMORS
The formation of properties promoting malignant transformation begins before the appearance of tumor cells at the level of inflammatory and precancerous processes. The basis for these properties is genomic instability of tumor cells. Genetic instability manife…
TUMOR BIOLOGICAL MARKERS AS THE BASIS FOR PERSONALIZED MEDICINE IN ONCOLOGY
The key role in the achievement of the main goals of personalized medicine in oncology i.e. treatment choice according to patient’s individual characteristics and biological properties of the tumor belongs to tumor molecular markers characterizing the specific…
ACTUAL ASPECTS OF MOLECULAR-BIOLOGY CLASSIFICATION OF BREAST CANCER
There is represented immunohistochemical and molecular biological characteristic of some histological types of breast cancer. The assessment of molecular biomarkers in breast cancer has two practical results: identification of risk groups, requiring additional…
METHODS OF NEXT GENERATION SEQUENCING IN THE IDENTIFICATION OF MOLECULAR GENETIC DETERMINANTS OF HEPATOCARCINOGENESIS
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
PROGNOSTIC SIGNIFICANCE OF KIT AND PDGFRA MUTATIONS FOR GASTROINTESTINAL STROMAL TUMORS
Introduction. Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of GI tract, are characterized by KIT and PDGFRA activating mutations that are predictive factors. KIT and PDGFRA mutations are present in 85% of GISTs and are associated…
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