Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
ANALYSIS OF GENES POLYMORPHISM: TNFΑ (-308G/A), IL6 (-174G/C), TGFΒ1 (-509 C/T), IL10 (-1082 G/A) AND PTPN22 (RS 2476601) (G/A) AT ATHEROSCLEROSIS
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
IGHT JUNCTION IN THE MAMMARY GLAND EPITHELIUM: POSSIBLE ROLE IN THE DEVELOPMENT OF ITS DYSFUNCTION
Introduction. Tissue barriers are the essential part of the compartmentalization in different organs. Tight junctions play a key role in paracellular transport. The selective permeability of tight junctions depends on expression of the claudin family of tight …
CLINICAL AND DIAGNOSTIC VALUE OF THE CONTENT OF TISSUE NEUROTRANSMITTERS IN FUNCTIONAL AND INFLAMMATORY BOWEL DISEASES
Introduction. There is observed an incidence rate of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The aim of the study. The study of the quantitative density of mast cells of the colon; enterochromaffin cells secreting serotonin, melat…
COMPARATIVE ASSESSMENT OF GROWTH FACTORS EXPRESSION IN PIGMENT NEOPLASMS OF SKIN
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…
A COMPARATIVE IMMUNOCYTOCHEMICAL ANALYSIS OF DNA METHYLATION PATTERNS IN HUMAN METAPHASE CHROMOSOMES OF ADULTS AND FETUSES
Introduction. DNA methylation is a key epigenetic modification providing the regulation of human genome activity in ontogenesis. DNA methylation patterns were described in the chromosomes from adult lymphocytes. DNA methylation patterns of the chromosomes from…
DEVELOPMENT OF AN IMMUNOENZYME METHOD FOR THE QUANTITATIVE DETERMINATION OF DOMOIC ACID IN SEAFOODS
Introduction. Amnesic shellfish poisoning is caused by consumption of seafoods contaminated with domoic acid (DA) and is accompanied by gastric colics, nausea, convulsions, hallucinations, loss of orientation and amnesia. As a preventive measure against these …
MOLECULAR ASPECTS OF IN VITRO VESSELS AGING
Introduction. Understanding of molecular and cellular mechanisms of vessels aging is the base of new approach creating of drugs for cardio-vascular pathology treatment. The goal of this work is the investigation of molecular and cellular mechanisms of vessels …
AGE-RELATED FEATURES OF THE SIGNAL MOLECULES’S PROFILE IN ENDOMETRIUM: PERSPECTIVES FOR DIAGNOSIS OF GYNECOLOGICAL PATHOLOGY
Introduction. Determination of the functional activity of the endometrium at the molecular-cellular level opens new perspectives for diagnosis and correction processes of accelerated aging and pathology of the female’s reproductive system. Objective – learning…
DEVELOPMENT OF MODULAR PEPTIDE CARRIER FOR TARGETED GENE DELIVERY INTO HUMAN TUMOR AND STEM CELLS
Introduction. Targeted gene delivery plays an exceptional role in the development of gene therapy. Peptide-based carriers are promising group of non-viral gene delivery vehicles due to biodegradability and easy structural and amino acid sequence modifications.…
COMPARATIVE STUDY OF BLOOD SERUM PROTEINS IN PATIENTS WITH SQUAMOUS CELL HEAD AND NECK CANCER
Introduction. Despite extensive researches, no molecular markers are currently available for predicting progression of squamous cell head and neck carcinoma. The paper presents results of pilot study of proteins in blood serum of healthy volunteers and patient…
TRANSLATION MODEL OF ALCOHOLIC CARDIOMYOPATHY
The aim of the study – the development of translational models of the alcoholic cardiomyopathy in rats to search and study the action mechanism of new original drugs for the treatment of this pathology. Methods. The complex of echocardiographic, electrophysiol…
ANALYSIS OF ASSOCIATION BETWEEN THE CHEMOKINE AND CHEMOKINE RECEPTOR GENES AND ESSENTIAL HYPERTENSION
Introduction. Chemokines are a group of proteins that plays an active role in the regulation of the vascular wall inflammation during the development of essential hypertension. The aim of the study was to investigate an association between essential hypertensi…