Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
SOMATIC AND GERMLINE MUTATIONS IN GASTRIC CANCER
Introduction. Most cases of gastric cancer (GC) occur sporadically. Until recently, diffuse hereditary gastric cancer associated with the CDH1 gene mutations was considered the only hereditary form (about 1–3% of all tumors of the stomach). However, a signific…
MAMMOSCINTIGRAPHY IN BREAST CANCER DIAGNOSIS
Introduction. Nuclear medicine imaging is widely used in oncology for the assessment of pathophysiologic changes occurring in a tumor. In this regard, the intensive study of diagnostic efficiency of the existing radiopharmaceuticals and the search for the new …
THE ROLE OF OXIDATIVE PROTEIN MODIFICATION IN REDOX-DEPENDENT REGULATION OF TUMOR CELL APOPTOSIS
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
THE INSULINE-LIKE GROWTH FACTOR SYSTEM IN OVARIAN CANCER METASTASIS: THE RELATION WITH P45 SER Β-CATENIN
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…
RECEPTOR GENE EXPRESSION OF ESTRADIOL AND PROGESTERONE IN ENDOMETRIAL POLYP'S TISSUE OF PRE- AND POSTMENOPAUSAL PATIENTS
Introduction, the aim of the study. An increase of anti-relapse endometrial polyp's therapy efficiency force us to explore estradiol (mER, ERα, ERβ) and progesterone (PR-A, PR-B, PGRmC1 and mPR) gene expression level in different histological types of polyp's …
PROGNOSTIC SIGNIFICANCE OF SERUM INSULIN-LIKE GROWTH FACTORS (IGF) AND IGF-BINDING PROTEINS LEVELS IN BONE SARCOMA PATIENTS
Introduction. Insulin-like growth factors (IGF) signaling system plays a major role in the development and progression of various sarcomas and other solid tumors, and therefore its components are regarded as promising diagnostic and prognostic tumor markers an…
ABOUT POSSIBILITY OF THE USE OF AFOBAZOL FOR TREATMENT OF ALCOHOLIC CARDIOMYOPATHY AND PREVENTION OF ITS CONCOMITANT COMPLICATIONS
The aim of the study. The proof of afobazole efficacy for treatment and prevention of alcoholic cardiomyopathy and attendant complications using the previously developed translational model. Materials and methods. Alcoholic cardiomyopathy was produced by conti…
CLINICAL AND IMMUNOHISTOCHEMICAL FEATURES OF CROHN'S DISEASE
Introduction. The central role in the pathogenesis of Crohn's disease (CD) is given an immune disorder. Communication immunohistochemical characteristics of the mucous membrane with the outcome of the disease has not been studied. The aim of the study. The aim…
ASSOCIATION ANALYSIS OF POLYMORPHISM IN MODIFYING GENES FOR BLOOD PRESSURE AND GENES FOR IMMUNE RESPONSE REGULATION WITH ISCHEMIC HEART DISEASE
Introduction. Genetic predispose to ischemic heart disease (CHD) are the priority directions in the study of etiological factors this condition. The aim of the study. Association analysis of polymorphism in modifying genes for blood pressure and genes for immu…
ОБЗОРЫ
AORTIC ANEURYSMS: ETIOLOGY AND PATHOMORPHOLOGY
The etiologic factors, features of pathogenesis and pathomorphology of thoracic and abdominal aortic aneurysms are considered in review. The morphologic and biologic features of the wall of thoracic aneurysms in Marfan's disease, Ehlers-Danlos, Loeys-Dietz, Tu…