Table of contents
ОБЗОРЫ
PROTEASOME FUNCTIONING IN PRETUMORAL AND NEOPLASTIC HUMAN EPITHELIUM
The review describes the characteristics of the ubiquitin-proteasome system involved in proteins degradation and its role in the transition of pretumor changes of the epithelium to cancer. According to modern concepts, the ubiquitin-proteasome system is active…
COMPUTATIONAL TOOLS AND METHODS FOR THE IMPLEMENTATION AND ELABORATION OF MOLECULAR DOCKING FOR ENZYMES OF THE MEDICAL DESTINATION
At present biomedical research is based on joint fulfillment of theoretical and experimental investigations of various derivatives of potential therapeutic destination. Well-balanced combination of noted studies is provided for the high reliability of ensemble…
MESENCHYMAL STEM CELL TRANSPLANTATION IN NEURODEREGENERATIVE DISEASES
Neurodegenerative diseases are a group of pathologies of the nervous system, which are characterized by progressive death of nerve cells and gradually increasing atrophy of the corresponding parts of the brain or spinal cord. In developed countries, an increas…
ON THE POSSIBLE USE OF EXOGENOUS HISTONES AND CATIONIC PEPTIDES IN MOLECULAR BIOTECHNOLOGY
The prospect of developing transport systems using histones for delivery of therapeutic agents possessing poor penetration characteristics through cellular membranes and tissue barriers has been investigated. A review of the literary, as well as proper data, a…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
ANALYSIS OF HERMINAL MUTATIONS IN ONCOGENES AND TUMOR SUPPRESSOR GENES IN WOMEN WITH MULTIPLE PRIMARY MALIGNANT NEOPLASMS
Introduction. Multiple primary malignant neoplasms (MPMN) most often develop in individuals with a hereditary predisposition to oncological diseases. There are inherited allelic variants of oncogenes, tumor suppressor genes and their combinations which disrupt…
THE STATE OF THE PROTEOLYSIS SYSTEM IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA ON THE BACKGROUND OF DIABETES MELLITUS TYPE 2
Introduction. The progression of inflammation in community-acquired pneumonia is associated with the activation of proteolytic enzymes, involved in eliminating the pathogenic agent, removing damaged structures. Proteinases are controlled by α1-proteinase inhib…
IMMUNOHISTOCHEMICAL STUDY OF TRANSCRIPTION FACTORS NEUROD1, PROX1, FOXM1, SOMATOSTATIN, AND CXCR4 RECEPTORS, CD38 IN GLIOBLASTOMAS TO DEVELOP NEW APPROACHES FOR THE TARGETED THERAPY
Currently, glioblastoma is an extremely malignant tumor, for which treatment only temozolomide is relatively effective. Aim to study the expression and variants of coexpression of transcription factors NeuroD1, Prox1, FoxM1, somatostatin receptors of the 2nd a…
STRUCTURALLY FUNCTIONAL ORGANIZATION OF THE GENOME OF A CLINICALLY SIGNIFICANT STRAIN HELICOBACTER PYLORI HP42K ISOLATED FROM THE PATIENT A HOSPITAL IN THE BELARUS REPUBLIC
Introduction. The use of genomic approaches allows a detailed studying of the pathogenetic potential of H. pylori bacteria. The aim of the study. To investigate the genome structural and functional organization of the H. pylori isolated in the Republic of Bela…
PROTECTIVE IMPACT OF BIOREGULATOR PEPTIDES BY EFFECT OF CONSTANT GEOMAGNETIC FIELD ON ORGANOTYPIC TISSUE CULTURE OF VARIOUS GENESIS
Introduction. The investigations of the magnetic-biological effects are actual because the modern technical works are related to the constant magnetic field (CGF) Purpose of the study was the investigation of impact of (CMF) on the tissues of various genesis –…
DETERMINATION OF FcγRIIIb (CD16) EXPRESSION ON THE SURFACE OF BLOOD NEUTROPHILS IN ANTI-PLAGUE VACCINATED PEOPLE
Aim. Comparative evaluation of FcγRIIIb (CD16) expression level on the surface of blood neutrophils in vaccinated and unvaccinated people before and after the interaction of сells in vitro with the plague microbe allergen (pestin). Materials and methods. Blood…
COLLAGEN EXCHANGE AND CONTENT OF MINERAL SUBSTANCES IN BONE TISSUE OF ANIMALS WITH EXPERIMENTAL DIABETES
Introduction. The risk of bone tissue disturbance leading to a disability of diabetes mellitus patients brisks up the study of the mechanisms of diabetic osteopathy. The aim of the study. To study the indices of collagen exchange, the content of components of …