Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
TECHNOLOGY FOR THE DETERMINATION OF MINOR FRACTIONS OF MODIFIED LIPOPROTEINS-α IN CORONARY ATHEROSCLEROSIS
Introduction. For the first time in clinical practice, diagnosis of different stages of lipidemia is conducted according to the level of blood lipids, lipoproteinsand catalase activity. This diagnostic approach can detect early stage of lipidemia against the p…
NEUROIMMUNOENDOCRINE PROFILE OF SARCOID GRANULEMA: EXPRESSION OF SIGNAL MOLECULES
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown etiology, which leads to disruption of the human respiratory system and can lead to damage to other systems. In clinical practice, doctors often run into difficulties in differentiating s…
EFFECT OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE DERIVATIVE ON THE COURSE OF NONALCOHOLIC FATTY LIVER DISEASE IN THE EXPERIMENT
Introduction. In the treatment of non-alcoholic fatty liver disease (NAFLD), which is the main cause of chronic liver disease, a certain role is assigned to hepatoprotectors. One of the hepatoprotectors currently used to treat NAFLD is ademetionine. At the sam…
THE ROLE OF SWI/SNF CHROMATIN REMODELER COMPOSITION IN SENSITIVITY TO GSK126 AND ABT263
Introduction. Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer characterized by frequent mutations in the ARID1A gene and low sensitivity to standard-of-care chemotherapeutic agents. The aim of the study. To determine the role of A…
IMMUNOHISTOCHEMICAL STUDY OF NEUROD1, NKX2.2, ISL1 TRANSCRIPTION FACTORS, SOMATOSTATIN AND CHROMOGRANIN A IN DIFFERENT FORMS OF CONGENITAL HYPERINSULINISM
Objective: a morphological study of the transcription factors NeuroD1, Nkx2.2, Isl1; somatostatin and chromogranin A in various forms of CH The methods included immunohistochemistry examination with antibodies to NeuroD1, insulin, somatostatin, ChrA, Nkx2.2, I…
EFFECT OF SMALL INTESTINE BACTERIAL OVERGROWTH SYNDROME ON THE COURSE OF BRONCHIAL ASTHMA
Aim. The work was carried out to study the role and features of small intestine bacterial overgrowth (SIBO) in the pathogenesis of bronchial asthma (BA). Material and methods. 80 BA patients were included in the study. SIBO was detected by the hydrogen breath …
LIVER ALVEOCOCCOSIS: ULTRASOUND AND MORPHOLOGICAL COMPARISONS
Introduction. Alveococcosis is a parasitic disease associated with the formation of the liver tumor-like lesion. This parasitic tumor has infiltrative growth and the ability to metastasize, that is, it exhibits the properties of malignant tumors. The disease i…
THE LEVEL OF EXPRESSION OF PROGESTERONE, ESTRADIOL AND VITAMIN D RECEPTORS IN MONONUCLEAR CELLS OF THE PERIPHERAL BLOOD OF PATIENTS WITH SURGICAL MENOPAUSE
Introduction. Patients with surgical menopause are at risk for an osteopenic syndrome. For adequate medical correction of osteoporosis, it is necessary to clarify the mechanisms of the pathogenesis of this condition. It is known that osteoclasts, the activatio…
ОБЗОРЫ
ROLE OF AUTOANTIBODIES TO GAD65 PROTEIN IN NEUROLOGICAL PATIENTS
Anti-glutamate decarboxylase (GAD65 isoform) autoantibodies are present in the blood of patients with such various autoimmune disorders, as diabetes type I, as well as relatively rare neurological diseases, such as Stiff Person syndrome and cerebellar ataxia. …
MOLECULAR MECHANISMS OF THE FUNCTIONING SYSTEM MOTHER–PLACENTA–FETUS IN WOMEN WITH OBESITY AND GESTATIONAL DIABETES MELLITUS
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …