Table of contents
ОБЗОРЫ
RELEVANT ASPECTS OF THE ACTIVATION OF MAST CELLS MECHANISMS IN ISCHEMIC AND REPERFUSION INJURY
This article provides a modern analysis of the literature on the mechanisms of activation of mast cells (MC) because they are regulatory cells that make up an important part of the immune system and are part of the first line of defense against various patholo…
GENE POLYMORPHISM IN TOLL-LIKE RECEPTOR AND ASSOCIATED DISEASES
Introduction. In recent years, there have been aroused and actively studied mutations associated with Toll-like receptor genes (TLRs). The emerging interest is related to the identification of many associations between the TLRs polymorphism and the development…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
AGE FEATURES OF THE EXPRESSION OF SIGNAL MOLECULES – PROTEIN P53, COLLAGEN TYPE II, VEGF AND VEGFR IN BIOPTATES OF INTACT MYOMETRY IN UTERINE MYOMA
Introduction. Leiomyomas also called fibroids, is the most common benign gynecological tumor in premenopausal women. The complex pathogenesis shows multiple biogenetical and multifactorial aspects to influence the etiology and growth of leiomyomas. A clinical …
THE ROLE OF TRANSCRIPTION AND GROWTH FACTORS IN THE DEVELOPMENT OF THE TUMOR PATHOLOGY OF THE PROSTATE GLAND
Introduction. The molecular mechanisms of the development of the prostate tumor pathology are associated with the activation of both androgen-dependent and androgen-independent signaling pathways, accompanied by the development of chronic inflammation and hypo…
EXPRESSION OF β-DEFENSIN-1 IN RAT COLON TISSUE
Introduction. At present, signaling pathways involved in the development of innate and adaptive immune responses and comprising, inter alia, the interaction of pattern-recognizing receptors, such as TLR, with antimicrobial peptides associated with inflammation…
ALLELES AND GENOTYPES DISTRIBUTION OF XENOBIOTIC BIOTRANSFORMATION GENES IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DISEASES
Introduction. In this research the frequency of variant alleles of genes for xenobiotic biotransformation in women living in a highly urbanized region of Western Siberia and having children with congenital heart diseases was studied. Materials and methods. Wom…
THE POSSIBILITIES OF ANOMALOUS VISCOSITY TIME DEPENDENCE METHOD FOR DETERMINATION OF CELL RADIOSENSITIVITY
Introduction. The initial state of an organism and its initial reactivity are the main prognostic criteria for the individual radiosensitivity evaluation. Particulars of the DNA structure and chromatin conformation determine in many respects the cell radiosens…
BIOIMPENDANCEMETRIA AS A METHOD FOR DIAGNOSIS OF VISCERAL OBESITY IN PEDIATRIC PRACTICE
Introduction. Visceral obesity is a key factor in the development of metabolic syndrome, which can lead to early disability and lower quality of life. The body mass index, which is widely used as a method of diagnosing obesity, does not allow for the different…
DETERMINATION OF THE DIFFUSION COEFFICIENT FOR THE DRUG RIVANOL IN THE HUMAN BUCCAL MUCOSA IN VITRO
Introduction. Dyes have long been successfully used in medicine as exogenous chromophores to increase the effectiveness of the interaction of light with biological tissues, as contrast agents and photosensitizers in diagnosis and photodynamic therapy. At prese…
CHANGES IN THE QUANTITATIVE COMPOSITION OF NEUROGLIA IN THE PREFRONTAL CORTEX OF RATS WITH MODELED POST-TRAUMATIC STRESS DISORDER
Introduction. Neuroglia plays an important role in maintaining the stable functioning of the CNS. Of particular importance are neuroglial cells in the organization of the immune system of the brain, activating both with physical, physiological damage, and with…