Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
FREQUENCY OF THE TERT RS2853669 POLYMORPHISM IN MELANOMA PATIENTS RESIDING IN THE EASTERN SIBERIA REGION
Introduction. The telomerase reverse transcriptase gene (TERT) promoter region is frequently mutated in different types of cancer. Several studies have shown patients who carry the mutation –245T>C (rs2853669) to have a worse prognosis. The aim of the study is…
THE EFFECT OF DOCETAXEL ON THE SURVIVAL AND CLONOGENIC ACTIVITY OF MCF-7 MAMMOSPHERES CULTURE ENRICHED WITH CANCER STEM CELLS
Introduction. Cancer stem cells (CSCs), which are less sensitive to chemotherapeutic drugs than other tumor cells, play a key role in the initiation and development of the tumor process. Maintenance of CSCs determines the risk of cancer recurrence. The aim of …
CORRELATION BETWEEN CARDIAC TROPONIN I LEVELS AND AREA OF MYOCARDIAL VASCULAR NECROSIS IN THE PATIENTS WITH FATAL OUTCOME
Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The pu…
INDIVIDUAL PECULIARITIES OF CHROMATIN CONFORMATIONAL STATE MODIFICATION UNDER EXPOSURE TO DIFFERENT PHYSICAL FACTORS
Introduction. The difference in the responsibility of organisms’ influences on the results of biological experiments and medical intervention. The chromatin conformational state is one of the main factors determining the cell response to the effect of differen…
EFFECT OF REGULAR AEROBIC PHYSICAL LOAD ON THE MORPHOMETRIC INDICATORS OF THE VISCERAL AND SUBCUTANIAL FAT TISSUE OF RATS
Introduction. Excess and lack of adipose tissue are associated with a violation of its functions, the mass of adipose tissue and its distribution play an important role in the development of metabolic disorders. The study of the influence of the main factors o…
FRACTIONAL ANISOTROPY ESTIMATION AS A WAY TO IDENTIFY PATHOLOGIES OF THE CEREBRAL ARTERIAL SYSTEM
Introduction. The correct functioning of the circulatory system allows providing stability of the brain and prevents the progression of pathological processes. The search for prognostic markers which make it possible to predict the appearance and adverse cours…
ОБЗОРЫ
REJUVENATING MANF FACTOR AND ITS FUNCTIONS IN NORMAL AND PATHOLOGICAL CONDITIONS
There are presented data about rejuvenating mesencephalic astrocyte-derived neurotrophic factor (MANF) and its physiological functions. This is a new neurotrophic factor, produced by the mesencephalic astrocytes and it is different from other factors by its ac…
ROLE OF GUT MICROBIOTA IN THE PROGRESSION OF HIV/AIDS INFECTION
Acquired immune deficiency syndrome is the final stage of the progression of the infection induced by HIV. Without antiretroviral therapy, the period from the infection to the death of the patient lasts for about 10 years. The gut microbiota changes were prove…
FUCOIDAN AS A COMPONENT IN THE DEVELOPMENT OF TARGET SYSTEMS FOR THE DELIVERY OF MEDICINAL SUBSTANCES
The growing interest in the group of highly sulfated heteropolysaccharides, defined as fucoidans, is due to a wide spectrum of their biological activity. The expansion of the direction of their application is associated with the search for applications in the …