Table of contents
ОБЗОРЫ
MicroRNA AND ITS’ TARGETS: BASICS OF BOIINFORMATIC SEARCH
MicroRNAs are defined as short non-coding molecules that regulate gene expression at the post-transcriptional level through complementary binding to the corresponding mRNA. This pairing leads to inhibiting of further translation by mRNA degradation, in other w…
MOLECULAR MECHANISMS OF POSSIBLE USE OF METABOLITES FOR PREVENTION, THERAPY AND REHABILITATION OF PATIENTS WITH COVID-19
The purpose of this review was to describe information about the etiology and pathogenesis of the main manifestations in patients with coronavirus infection COVID-19 and the molecular mechanisms of the possible use of metabolite drugs. Material and methods. Th…
HPgV INFECTION
Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to …
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE INFLUENCE OF L-AMINO ACIDS ON THE VIABILITY OF NEUROENDOCRINE PC12 CELLS LINE
Introduction. It was shown, that L-amino acids can take part in regulation of the main physiological processes. Various combination of L-amino acids takin into account of its biological activity can apply for peptide drugs synthesis for target therapy of socia…
MITOCHONDRIA PROTEINS OF CARDIOMYOCYTES AS MOLECULAR TARGETS OF THE PREPARATION V007
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…
SALIVA CONCENTRATION OF SIRTUINS: PERSPECTIVES OF APPLICATION FOR CORONARY HEART DISEASE DIAGNOSTICS AND AGING RATE
The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «nor…
INNATE AND ADAPTIVE IMMUNITY DURING INFECTION AND IMMUNIZATION WITH INACTIVATED TICK-BORNE ENCEPHALITIS VACCINE
Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …
EFFECT OF IMMOBILIZATION OF GLYCOPROTEINS OF THE BAKER’S YEAST CELL WALL ON THEIR IMMUNOMODULATORY ACTIVITY
The aim of the study was to study the effect of chemical immobilization of yeast cell wall glycoproteins on their ability to activate cytokine production by human peripheral blood cells. Methods. A comparative analysis of the immunomodulatory activity of yeast…
ANTIOXIDANT ACTIVITY OF POLYPHENOLS IN LICORICE BEANS (GLYCYRRHIZA GLABRA L.)
Introduction. The worldwide trend towards green technologies has increased interest in the development and use of natural, highly-efficiency and inexpensive plant antioxidants to replace existing synthetic ones. Purpose of the study. study of the composition o…
ROLE OF REACTIVE GLIA IN MODULATION OF NEURO- AND SYNAPTOGENESIS IN VITRO
Introduction. Activation of glial cells by lipopolysaccharide leads to the release of proinflammatory cytokines and the development of neuroinflammation, which, in turn, affects the processes of neuro- and synaptogenesis. However, the specific mechanisms of ne…