Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
A comparison of the protein composition from coronary atherosclerotic plaque at different stages of development
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
Development of 3d structures for corneal fibroblasts
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Molecular features of nephropathy associated with disorder of urate metabolism
Introduction: Urate nephrolithiasis is a common form of urolithiasis. The development of new methods for pharmacological correction of this disorder requires their practical laboratory assessment. So far, it is necessary to determine the most typical biochemic…
THE ASSOCIATION OF rs34643859 GENE KCNS1, rs12804550 GENE SCN4B, rs4514993 GENE SCN11A WITH THE SUDDEN CARDIAC DEATH
Introduction. Single nucleotide polymorphisms rs34643859 of the KCNS1 gene, rs12804550 of the SCN4B gene, and rs4514993 of the SCN11A gene were revealed in the analysis of the results of whole exome sequencing of a group of young man died by sudden cardiac dea…
Proliferation effect of peptides on orgatypic tissue culture of mammalian and birds
Introduction. The study of the mechanisms of multicellular system regulation and of complex balance between two basic physiologic processes, proliferation and apoptosis, is actual task of the modern molecular biology and medicine. Purpose of the study – the in…
Alterations in mRNA expression of rat astrocytes co-cultured with c6 glioma cells and impact of glioma-conditioned astrocytes on dendritic cell maturation
Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…
The correlation of laser correlation spectroscopy and cytokines in the mixed saliva of patients undergoing orthodontic treatment
The aim was to correlate the content of cytokines/chemokines in the oral fluid of patients undergoing orthodontic treatment with the results of laser correlation (LC) spectroscopy in order to develop approaches to prenosological diagnostics. Methods. Oropharyn…
Analysis of biochemical changes in muscular tissue of rats with hypercholesterolemia combined introduction of simvastatin and coenzym Q10
Introduction. Statins are a group of effective lipid – lowering medications. A common side effect of long-term statin use is myopathy. The mechanism of its development is not fully understood at the molecular level, making it difficult to find effective drugs …
ОБЗОРЫ
Influence of post-ischemic physical loads on brain cell assemblies in cerebral hypoperfusion
A wide range of diseases: stroke, Alzheimer’s disease, brain injury, etc., is based on cerebral hypoperfusion. Vascular dementia, which is the equivalent of cerebral hypoperfusion, is one of the most common cognitive disorders in older people following Alzheim…