Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
MOLECULAR AND GENETIC POTENTIAL OF THE VIRULENT EFFECTS OF ESCHERICHIA COLI ISOLATES TAKEN FROM ULCER COLITIS PATIENTS
Introduction. The human microbiota is part of the «human-microbiome» system and is actively involved in developing various pathological responses and conditions in the body. It is currently essential to study the pathogenesis of ulcerative colitis (UC), a poly…
COLLAGEN METABOLISM DYNAMICS IN TISSUES OF RATS WITH EXPERIMENTAL DIABETES ON THE BACKGROUND OF CHRONIC EMOTIONAL STRESS
Introduction. Developing of chronic emotional stress reduces adaptive capabilities of people ill with diabetes mellitus causing the condition of decompensation with significant elevation of counterinsular hormones production and further progressive metabolic d…
IMPACT OF WEAKENED GEOMAGNETIC FIELD ON THE ORGANOTYPIC CELL CULTURE OF VARIOUS GENESIS
Introduction. The investigations of the magnetic-biological effects are actual because of the permanent impact of changing Earth geomagnetic field on the live organisms. Purpose of the study was to investigate the impact of the weakened geomagnetic field (WGF)…
NOVACUTAN PREPARATIONS AS POTENTIAL DERMATOGEROPROTECTORS: MOLECULAR-MICROSCOPIC STUDY
Introduction. The work is devoted to study of new medication Novacutan SBio and Novacutan YBio as potential geroprotectors for biorevitalization of the skin. Klotho was used as a marker – to assess the overall aging of cells; MTH1 – the antioxidant status of c…
THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE STRUCTURAL AND FUNCTIONAL SPECIFIC OF FACE SKIN IN ELDERLY WOMEN
The actual goal of molecular medicine is the search for effective and safe peptide bioregulators for applying in cosmetology. Elderly women now need the applying of innovative methods of cosmetology. It allows such persons to avoid the visible manifestation of…
THE ALTERATION OF MICRORNA EXPRESSION PROFILES IN CUTANEOUS MALIGNANT MELANOMA AND BENIGN MELANOCYTIC NEVI
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
ПЕРЕДОВАЯ СТАТЬЯ
ORGANIZATION OF WORK OF A MULTIDISCIPLINARY HOSPITAL IN A PANDEMIC OF A NEW CORONAVIRUS INFECTION
The appearance and spread of a new coronavirus infection around the world has led to the urgent need to open additional hospitals to receive infectious patients. The Department of Health of the city of Moscow decided to re-profile the city’s multidisciplinary …
ОБЗОРЫ
METHODS FOR MODELING HYPOTHYROIDISM: CLASSIFICATION AND MODELING PRINCIPLES
Researchers widely use methods for modeling experimental pathological conditions to develop and preclinically evaluate the effectiveness of new drugs and study structural and functional changes in various organs and tissues. Hypothyroidism (hypofunction of the…
THE ROLE OF VEGF AND microRNA IN THE FORMATION OF THE ENDOMETRIOID PHENOTYPE OF ENDOMETRIAL CELLS
This review attempts to generalize current data on the role of microRNAs in the pathogenesis of endometriosis and their pathogenetic relationship with the main pathomorphological phenomena in this pathology. Nowadays, many microRNAs were studied to clarify the…
ATOPIC DERMATITIS: A MODERN VIEW OF INTERCELLULAR INTERACTIONS
Atopic dermatitis (AD) is characterized by a violation of the epidermal barrier dysfunction. This review examines the work of the authors who describe mutations in the filaggrin gene as predisposing factors for the development of AD and describe the dysfunctio…