Table of contents
ОБЗОРЫ
SORCIN AS A POTENTIAL TARGET IN MOLECULAR DIAGNOSTICS AND TARGETED THERAPY OF LUNG CANCER
Lung cancer occupies the leading position in at the structure of oncological morbidity in the developed countries. The overall five-year survival rate for lung cancer isn’t exceed to 10–20% even using of the entire modern arsenal of therapeutic methods. Multip…
THE ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN THE PATHOGENESIS OF DEPRESSIVE DISORDERS
The neurotrophic hypothesis of depressive disorders has gained widespread recognition nowadays. This review is devoted to the brain-derived neurotrophic factor (BDNF) system in the pathogenesis of depression and major depressive disorder. We describe the struc…
Osteopontin as a factor of neuroinflammation in chronic non-infectious diseases
Osteopontin (OPN) is a highly phosphorylated multifunctional glycosphoprotein with important functional activity in cancer and cardiovascular diseases, diabetes mellitus (DM), kidney and liver pathology, inflammatory process, and also influencing cell viabilit…
THE MODULATING ROLE OF HISTAMINE IN NEUROIMMUNE INTERACTIONS
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
COMPARING OF CYTOKINE CONTENT IN SERUM AND PLATELET SOLUBLE PREPARATIONS, PRODUCED IN DIFFERENT WAYS
Introduction. Human platelets maintain big reparative and regenerative potential. The biochemical content of platelet preparations seriously depends on methodic features. The aim of the study. To study cytokine content in different types of platelet soluble pr…
IDENTIFICATION OF SHORT PEPTIDES: OPTIMIZATION OF TARGET THERAPEUTIC PROPERTIES OF THE THYMUS MEDICINE
Introduction. The identification of molecular components contributes to the realization of the targeted properties of multicomponent drugs to study their molecular mechanism and therapeutic targets. The polypeptide complex isolated from cattle thymus (thymalin…
KINETIC PARAMETERS OF THE CHANGE OF OPTICAL PROPERTIES OF THE GINGIVA UNDER IMMERSION IN GLYCEROL: EX VIVO RESEARCH
Introduction. The oral cavity is the beginning of the human digestive system and the presence of pathological changes in it: a shift in the dynamic balance, composition, and types of microorganisms inhabiting the oral cavity; color change; the appearance of pa…
EXPRESSION OF GLIAL MARKERS, CYTOKINES AND MARKERS OF NEUROGENESIS IN THE MOUSE HIPPOCAMPUS DURING AGING AND IN RESPONSE TO LIPOPOLYSACCHARIDE
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
EFFECT OF PNPLA3, SERPINA1, AND HFE GENES POLYMORPHISMS ON THE COURSE OF NONALCOHOLIC FATTY LIVER DISEASE
Introduction: nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. But it remains unclear what factors influence the progression of the disease. It is interesting to study the influence of the genetic aspect on the course of NAF…