Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
FORECASTING THE DEVELOPMENT OF ACUTE PANCREATITIS BASED ON MOLECULAR GENETIC STUDY
Introduction. Molecular genetic research methods suggest the development of certain forms of pancreatitis and its complications. Aim of the study. Identification of risk factors for the development of acute forms of pancreatitis based on molecular genetic stud…
Features of local expression of mRNA, IL-1β, IL-18, CCL2/MCP-1 in modeling pigment epithelium atrophy and retinal degeneration in the experiment on rabbits
Introduction. Degenerative retinal diseases are considered as the leading cause of blindness and low vision worldwide. The last studies have provided convincing evidence of the involvement of immunological factors in the development and progression of the dise…
FEATURES OF EXPRESSION OF β-AMYLOID IN CEREBRAL ENDOTHELIAL CELLS IN EXPERIMENTAL ALZHEIMER’S DISEASE
Introduction. The formation of neurofibrillary plexuses and the accumulation of senile plaques in the parenchyma and cerebral vessels are the key pathological signs of Alzheimer’s disease presenting a neurodegenerative disease. The main component of senile pla…
PHASE I CLINICAL STUDY OF A NEW RADIOPHARMACEUTICAL BASED ON RECOMBINANT TARGET MOLECULES DARPIN9_29 LABELED WITH 99mTECHNETIUM FOR RADIONUCLIDE DIAGNOSIS OF THE Her2/neu-POSITIVE BREAST CANCER
Introduction. The main attention of researchers is paid to the study of one of the members of the EGF family – the receptor of epidermal growth factor 2 (Her2/neu), the overexpression of which is detected in 15–20% of cases of invasive breast cancer and had an…
PROTECTIVE EFFECT OF CODED L-AMINO ACIDS IN CYTOSTATIC PRESENCE ON THE DEVELOPMENT OF ORGANOTYPIC CULTURE OF TISSUES OF DIFFERENT GENESIS
Introduction. The cytostatics, inhibiting the cellular proliferation, are using in clinic for the inhibition of tumor development in patients. However, the adverse events can occur because of the damage of health cells of other tissues. A delay or decrease of …
ОБЗОРЫ
HORMONE ADROPINE: ITS EFFECT ON AGE-ASSOCIATED DISEASES
The purpose of the review was the search and analysis of the data about hormone adropin, similar to the known hormone irisin, and its effect on the pathology, associated with aging. Adropin is expressed in many following organs as referred to CNS, in liver, ki…
ON THE ROLE OF PCSK9 IN THE DEVELOPMENT OF ATHEROSCLEROSIS: MOLECULAR ASPECTS
Due to the discovery of the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the establishment of its role in lipoprotein metabolism, it became possible to deliver new groups of effective drugs for the treatment of dyslipidemia. The main function of P…
Protocol to evaluate clinical tumor tissue sample for genetic studies
The article represents a literature review on the molecular genetic methods with routine histological material for clinical purposes within oncology service. The protocol to evaluate the quality of tumor tissue samples for molecular genetic studies is proposed…