Table of contents
ОБЗОРЫ
TRANSCRIPTOME ANALYSIS IN ONCOLOGY AND DERMATOLOGY
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…
POSTTRANSLATIONAL PHOSPHORYLATION AND FRAGMENTATION OF CARDIAC TROPONIN T: MECHANISMS AND SIGNIFICANCE
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
PROVOCATION OF OXIDATIVE STRESS BY HEAVY METALS AS A POSSIBLE TRIGGER FACTOR IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
MITOCHONDRIA – INTRACELLULAR TARGETS OF GEROPROTECTIVE EFFECT OF V007
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
SIRTUINS: PREDICTIVE MOLECULAR DIAGNOSIS OF ALZHEIMER’S DISEASE IN LONG-LIVER
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
CIRCADIAN RHYTHM OF MELATONIN RECEPTOR EXPRESSION IN THE BUCCAL EPITHELIUM OF PREGNANT WOMEN AND THEIR NEWBORN CHILDREN: DEVELOPMENT OF MOLECULAR MARKERS FOR PROGNOSIS OF DELAYED POSTNATAL PATHOLOGY
Introduction. Buccal epithelium (BE), in which cells the expression of signal molecules reflecting the state of homeostasis of the body in normal and pathological conditions is verified, is used as a diagnostic material for a number of diseases in adults. The …
Lungs and liver remodeling depends on the presence of metastasis in melanoma B16-bearing mice
Pre-metastatic niche formation precedes tumor dissemination although the mechanisms of it remain unclear. Therefore, the aim of the study was to evaluate the expression of molecules characterizing the microenvironment remodeling in target organs lungs and live…
INFLUENCE of κ- and λ-CARRAGEENANS FROM CHONDRUS ARMATUS ON COLON CANCER CELLS PROLIFERATION RKO and HCT-116
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…
GENETIC PREDICTORS OF SPORADIC CONGENITAL HEART DEFECTS IN CHILDREN
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…
THE ROLE OF SOME GENETIC POLYMORPHISMS OF IL-10 IN THE DEVELOPMENT OF VARICELLA IN MILITARY PERSONNEL
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…