Table of contents
ОБЗОРЫ
СYTOKINES FOR ALLERGIC DISEASES
The majority of IgE binds with Fcε mast cells receptors. Repeated contacts between allergen and specific IgE on the surface of mast cells result in Fcε-receptors cross-linking, degranulation and release of inflammation mediators such as histamine, proteases, c…
INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF CHRONIC HEART FAILURE
The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of CHF. Material and methods. A analysis of the main foreign and domestic sources on PubMed, MedLine, eLIBRARY databases over the last 20 years has been ca…
COMPENSATORY MUTATIONS AS A MECHANISM FOR PRESERVING VIRULENCEAND VIABILITY OF DRUG-RESISTANT FORMS OF MYCOBACTERIUM TUBERCULOSIS
Tuberculosis remains one of the leading causes of death from infectious diseases in the world. According to WHO data, tuberculosis is diagnosed annually in more than 100 million people and causes 4.5 thousand deaths. Despite a steady decline in the main epidem…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED
The main reason for the severity of COVID-19 and the death of patients is the «cytokine storm» – a strong inflammatory response caused by SARS-CoV-2. Macrophages, immune cells that help eliminate pathogens and repair damaged tissues, play a key role in the exp…
AED PEPTIDE ACTIVATES GENE EXPRESSION AND DIFFERENTIATION PROTEINS SYNTHESISOF HUMAN SKIN FIBROBLASTS DURING REPLICATIVE AGING
The aim of this work is to study the effect of the AED peptide on fibroblast differentiation of human skin when aging in vitro. Methods. The study was conducted on DF-1 cell line (human dermal fibroblasts (mesenchymal stem cells)) isolated from the skin of the…
STUDYING OF P-, E-SELECTINS AND GLYCOPROTEIN LIGAND PSGL-1 LEVEL IN BLOOD SERUMOF PATIENTS WITH ATHEROSCLEROSIS OF THE ARTERIES OF LOWER LIMB
Introduction. The study of intermoleculars interactions can contribute to the development of ideas about the violation of the endothelium,s adhesive function as one of the pathogenetic links in the development of peripheral artery diseases of atherosclerotic e…
PURINERGIC REGULATION OF STONES ELIMINATION FROM THE UPPER PARTOF THE URETER DURING LITHOKINETIC THERAPY
The reasons for the low efficiency of the α1A-blockers using in the scheme of lithokinetic therapy (LCT) remain unclear. The aim of the study was to evaluate the activity of the purinergic P2X1 receptor in the blockade of the α1A-adrenergic receptor during LCT…
DECREASE IN ANG AND VEGF mRNA LEVELS DURING PROGRESSIVE ANGIOGENESISOF THE LIVER VENOUS SYSTEM OF WISTAR RATS IN EXPERIMENTAL CIRRHOSIS
Introduction. Currently, understanding the molecular mechanisms of pathological angiogenesis remains a fundamental problem in hepatology. The aim of this work was to find a relationship between the level of mRNA expression of the ang, vegf genes and angiogenes…