STUDYING OF P-, E-SELECTINS AND GLYCOPROTEIN LIGAND PSGL-1 LEVEL IN BLOOD SERUMOF PATIENTS WITH ATHEROSCLEROSIS OF THE ARTERIES OF LOWER LIMB

Introduction. The study of intermoleculars interactions can contribute to the development of ideas about the violation of the endothelium,s
adhesive function as one of the pathogenetic links in the development of peripheral artery diseases of atherosclerotic etiology.
The aim of the study. To study the content of Р- and E-selectins, a high-affinity glycoprotein ligand PSGL-1; to identify correlations
between the represented values in the blood serum of patients with atherosclerosis of the lower extremities arteries.
Methods. Quantitative determination of selectins P, E and glycoprotein ligand PSGL-1 by the sandwich method of ELISA in blood
serum.
Results. A decrease in the concentrations of selectins P and E, an increase in the concentration of the glycoprotein ligand of selectins
PSGL-1 was revealed; a moderate negative correlation (r = -0,48) between the concentration of selectin P and the concentration of PSGL-1
in the blood serum of patients with atherosclerosis of the arteries of the lower extremities was detected.
The findings of the study are as follows:
• a statistically significant decrease in the concentration of selectin P in the blood serum of patients with atherosclerosis of the arteries
of the lower extremities was revealed;
• a statistically insignificant decrease in the concentration of selectin E in the blood serum of patients with atherosclerosis of the arteries
of the lower extremities was detected;
• a statistically significant increase in the concentration of glycoprotein ligand selectins PSGL-1 in the blood serum of patients with
atherosclerosis of the arteries of the lower extremities was detected;
• a moderate negative relationship was found between the concentration of selectin P and PSGL-1 (r = -0.48) in the blood serum of
patients with atherosclerosis of the arteries of the lower extremities.
All of the above changes can be related to the death of endotheliocytes and their reduction in synthesis of intercellular adhesion molecules,
which is reflected in the disruption of the adhesive function, which is a component of endothelial dysfunction.

N.V. Korotkova, R.E. Kalinin, I.A. Suchkov, L.V. Nikiforova, A.N. Ryabkov
Ryazan State Medical University, Vysokovoltnaya, 9, Ryazan, 390026