Table of contents
ОБЗОРЫ
SARCOIDOSIS: MOLECULAR MARKERS AND TARGETS FOR TARGETED DIAGNOSIS AND THERAPY
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing persona…
THE ROLE OF THE INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF BRONCHIAL ASTHMA
It is currently being discussed that the microbiota of the gastrointestinal tract and its metabolites affect the course of bronchial asthma (BA). The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of ВА. Ma…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
PROGASTRIN-RELEASING PEPTIDE (proGRP) AND NEURON SPECIFIC ENOLASE (NSE) IN SURVIVAL PROGNOSIS IN PATIENTS WITH SMALL CELL LUNG CANCER
Introduction. Small cell lung cancer (SCLS) is a highly aggressive type of tumor, and various compounds are considered as potential biochemical markers of its prognosis, including neuron-specific enolase (NSE), chromogranin A (CgA), and prograstrin releasing p…
EFFECT OF TRIPEPTIDES ON GROWTH OF ORGANOTYPIC CULTURE OF DIFFERENT GENESIS TISSUES
Tripeptides are physiological products of protein degradation and informational molecules. AED (Ala-Glu-Asp), EDR (Glu-Asp-Arg), EDG (Glu-Asp-Gly) peptides have geroprotective, neuroprotective, reparative and antioxidant properties. The aim of the work is to e…
MOLECULAR MARKERS OF ENDOMETRIAL CARCINOMA AND ASSOCIATED CLINICOPATHOLOGICAL FEATURES
Introduction. In 2013 The Cancer Genome Atlas research group divided the molecular aberrations in endometrial cancer into four subtypes: POLE mutations, microsatellite instability, copy-number low and copy-number high. These subtypes have different prognosis a…
NEUROIMMUNE CHANGES IN ATOPIC DERMATITIS DURING PREGNANCY
Introduction. An increase in the number of patients with atopic dermatitis (AD) among pregnant women is recorded annually. However, the pathogenesis of AD during pregnancy is not fully understood. Exacerbations of AD during pregnancy require in-depth study, si…
РЕТРАГИРОВАНА / RETRACTED INVESTIGATION OF THE METABOLITE COMPOSITION OF LACTIC ACID BACTERIA STRAINS ON THE BASIS OF A PROBIOTIC DRUG
Introduction. Lactic acid bacteria synthesize antimicrobial substances of various nature: acids, alcohols, diacetyl, reuterin, hydrogen peroxide, carbon dioxide, etc. The Food and Drug Administration (USA) and the European Food Safety Authority have recognized…
MOLECULAR MECHANISMS OF NEUROPROTECTION OF 3-[(E)-3-(3,5-DITRET-BUTYL-4-HYDROXYPHENYL)-3-OXOPROP-1-ENYL]-6-METHOXY-CHROMENE-4-ONE IN EXPERIMENTAL TRAUMATIC BRAIN INJURY
Introduction. Neuroprotection in traumatic brain injury is a promising area of therapy for cerebral disorders. Neuroprotective effect can be implemented by a action on variety molecular targets, a change in the activity of which leads to the elimination of pat…
EFFECT OF POLYPEPTIDE COMPLEXES ON THE DEVELOPMENT OF SKIN ORGANOTYPIC TISSUE CULTURE OF DIFFERENT AGE RATS
Introduction. The creation of peptide bioregulators that contribute to the preservation of the basic physiological functions of the body is an urgent task of modern biology and medicine. The aim of the study was to evaluate the effect of polypeptide complexes …