Table of contents
ОБЗОРЫ
KISSPEPTINS: MOLECULAR MECHANISMS OF RESPIRATORY SYSTEM PATHOLOGY
The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and m…
SASP OF ENDOTHELIUM AND VASCULAR SMOOTH MUSCLE CELLS: ROLE IN THE PATHOGENESIS AND THERAPY OF ATHEROSCLEROSIS
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
CELLULAR SENESCENCE: MOLECULAR BIOLOGY AND MORPHOLOGY
Cellular senescence is a reaction of cells to damage, which consists in a full stop of the cell cycle, changes of the signaling pathways and secretory activity associated with aging. Regardless the inducing factor, cellular aging of different types have a simi…
THE ROLE OF PHYSICAL ACTIVITY IN THE PROCESSES OF NEUROGENESIS IN THE HIPPOCAMPUS
The purpose of this review was to determine the role of physical activity as an integral component of environmental enrichment in the processes of neurogenesis in the rodent hippocampus. Material and methods. The full-text search has been carried out in the Me…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
GALECTIN-3, HAPTOGLOBIN AND PROANGIOGENIC FACTORS IN GASTRIC CANCER
Introduction. Stomach cancer in Russia occupies the 4th place among most frequent malignant neoplasms, after tumors of the lung, breast and colon. The search for new diagnostic and prognostic markers of this pathology is an urgent task of modern molecular onco…
Eosinophils are predictors of susceptibility to thrombosis and severe course of Covid-19 in various types of therapy
The creation by COVID-19 of methods for prophylactic of these complications as blood hypercoagulation, leading to thrombosis and polyorganic insufficiency, is an urgent task of modern biology and medicine. The aim of the study was to develop the simple methods…
SIGNAL TRANSDUCTION OF INEFFICIENT ELIMATION OF SMALL STONES FROM THE MIDDLE THIRD OF THE URETER
Аim of the study was to evaluate the activity of receptors that control contraction (α2-adrenergic receptor, purine P2X1 and P2Y receptors, angiotensin AT1 receptor, TxA2 receptor) and relaxation of smooth myocytes (adenosine A2 receptor) during standard litho…
INDUCTION OF APOPTOSIS OF PROSTATE CANCER CELLS BY THE EXTRACT OF THE FRESHWATER SPONGE
Introduction. Prostate cancer (PC) is by far the most commonly diagnosed malignant neoplasm of the urinary system. The pathogenesis and molecular mechanisms of prostate cancer remain incompletely understood. There are reports of the presence in the extracts of…
EFFECT OF DIPEPTIDES ON CELLULAR GROWTH IN ORGANOTYPIC CULTURE OF TISSUES FROM YOUNG AND OLD RATS
Dipeptides are physiological products of protein degradation and informational molecules. Asp-Pro, Asp-Ala, Glu-Ala peptides have geroprotective, reparative properties. The aim of the work is to evaluate the effect of the Asp-Pro, Asp-Ala и Glu-Ala peptides on…
ACTIVITY OF THE 4-1BB/4-1BBL SIGNALING PATHWAY IN PATIENTS WITH COLON TUMORS
Background. Protein 4-1BB (CD137) enhances the activity of T-cells, prevents their death, and promotes the production of cytokines, which makes it a powerful co-stimulating agent. Currently, the use of this glycoprotein is being studied in order to influence t…