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SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED
The main reason for the severity of COVID-19 and the death of patients is the «cytokine storm» – a strong inflammatory
response caused by SARS-CoV-2. Macrophages, immune cells that help eliminate pathogens and repair damaged tissues, play a key role
in the expression of inflammatory mediators. In addition to known cytokines, macrophages express the PD-L1 protein, a ligand of the PD1
apoptosis receptor.
The aim of the study was to comparatively analyze the levels of soluble forms of the programmed cell death receptor (sPD-1) and its
ligand (sPD-L1), as well as biochemical and hematological parameters in the blood of patients who underwent COVID-19.
Material and methods. We carried out sPD-1 and sPD-L1 enzyme immunoassay and biochemical studies in 72 employees of the
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation who have undergone
COVID-19. The control group consisted of 57 healthy donors. The fact of the disease was confirmed by the presence of antibodies to class G
immunoglobulins (SARS-Cov-2 IgG) in the blood serum using the ELISA test system Antigma-G (Generium, Russia).
N.E. Kushlinskii, I.V. Babkina, E.S. Gerstein, N.V. Lyubimova, Yu.S. Timofeev,
E.A. Korotkova, G.N. Zubrikhina, T.V. Davydova, O.V. Somonova, I.S. Stilidi
N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe shosse, 24, Moscow, 115522, Russian Federation
How to cite
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V. (2022). SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED. Molecular Medicine, 22(2), 28–31. https://doi.org/10.29296/24999490-2022-02-04
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V., “SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED”, Molecular Medicine, vol. 22, no. 2, pp. 28–31, 2022. doi: 10.29296/24999490-2022-02-04.
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V. “SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED.” Molecular Medicine, vol. 22, no. 2, 2022, pp. 28–31. https://doi.org/10.29296/24999490-2022-02-04
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V. 2022. “SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED.” Molecular Medicine 22(2): 28–31. https://doi.org/10.29296/24999490-2022-02-04
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V. (2022) ‘SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED’, Molecular Medicine, 22(2), pp. 28–31. doi: 10.29296/24999490-2022-02-04.
Kushlinskii N.E., Babkina I.V., Gerstein E.S., Lyubimova N.V., TimofeevYu.S., Korotkova E.A., Zubrikhina G.N., Davydova T.V. SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED. Molecular Medicine. 2022;22(2):28–31. doi:10.29296/24999490-2022-02-04.
TY - JOUR
TI - SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED
AU - Kushlinskii N.E.
AU - Babkina I.V.
AU - Gerstein E.S.
AU - Lyubimova N.V.
AU - TimofeevYu.S.
AU - Korotkova E.A.
AU - Zubrikhina G.N.
AU - Davydova T.V.
JO - Molecular Medicine
PY - 2022
VL - 22
IS - 2
SP - 28
EP - 31
DO - 10.29296/24999490-2022-02-04
UR - https://new.molmedjournal.ru/en/24999490-2022-02-04
ER -
@article{article699,
title = {SOLUBLE FORMS OF PROGRAMMABLE CELL DEATH RECEPTOR sPD-L AND LIGAND sPD-L1,AS WELL AS SOME BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN THE BLOOD OF COVID-19 DISEASED},
author = {Kushlinskii N.E. and Babkina I.V. and Gerstein E.S. and Lyubimova N.V. and TimofeevYu.S. and Korotkova E.A. and Zubrikhina G.N. and Davydova T.V.},
journal = {Molecular Medicine},
year = {2022},
volume = {22},
number = {2},
pages = {28--31},
doi = {10.29296/24999490-2022-02-04},
}
