Table of contents
ОБЗОРЫ
Molecular mechanisms of tumor drug resistance
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
THE GUT MICROBIOTA IS THE MISSING LINK IN THE PATHOGENESIS OF CELIAC DISEASE
Results. During the analysis of the published pathogenesis of celiac disease (CD) is actively discussed. It is assumed that the change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and envi…
BIOCHEMICAL MECHANISMS OF FERROPTOSIS
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the development of ferroptosis; the main conditions for the development of this type of cell death are described, and cell markers and targets for the induction of ferropto…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE EFFECT OF ANTITUMOR DRUGS ON THE COURSE OF TUBERCULOSIS IN THE EXPERIMENT
Introduction. Lung cancer and tuberculosis, make a significant affect to the morbidity and mortality of the population in Russia and in the world. Strategy of medication therapy has not been developed for cases when these diseases are combined. The aim of the …
Activation of the MAPK signal cascade components phosphorylation involved in the formation of the G0-positive tumor phenotype
Introduction. Among the heterogeneous population of tumor cells, there are so-called dormant and senescent cells located in the G0 phase of the cell cycle. The transition to the G0 phase is a stress response mediated, for example, by treatment with chemotherap…
SELECTIVE SCREENING FOR IMMUNE DISORDERS IN NEWBORN AND INFANT CHILDREN
Introduction. Primary immunodeficiency states (PIDs) are a heterogeneous group of innate immune disorders. A feature of the clinical manifestations of PID is that they are nonspecific for specific clinical forms. With untimely diagnosis and the absence of path…
STUDYING THE RELATIONSHIP OF IRON CONCENTRATION IN BLOOD SERUM WITH FERRITIN, TRANSFERRIN AND OTHER CHEMICAL ELEMENTS
Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various a…
THE GENDER FACTOR EFFECT FOR THE EDOCRYNE FUNCTION OF MESENCHYMAL TISSUES IN CHILDREN AND ADOLESCENT
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
CARBONYLATION OF SPERMОPLASM PROTEINS IN PATIENTS WITH REDUCED FERTILITY
Introduction. In the publications of many authors, there is evidence that the mechanism of development of chronic prostatitis and varicocele is oxidative stress, leading to a decrease in male fertility. This problem requires a deeper study. The aim of the stud…