Table of contents
ОБЗОРЫ
MECHANISMS OF CELLULAR PROTECTION AGAINST NANOMATERIALS
Introduction. Entry of inorganic and organic nanomaterials through respiratory tract, skin and digestive system increases the risks of immunological disorders, hereditary and oncological diseases. Localization and stability of nanoparticles are determined by t…
MOLECULAR MECHANISMS OF NEUROINFLAMMATION AND SLEEP DEPRIVATION IN THE DEVELOPMENT OF AGE-ASSOCIATED COGNITIVE DYSFUNCTION
Introduction. Proinflammatory cytokines produced in elevated concentrations in the elderly significantly impair neurogenesis in the dentate gyrus of the hippocampus, long-term potentiality, alter neuronal morphology and function, and increase apoptosis. This l…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
PREDICTIVE CLINICAL AND LABORATORY ASPECTS OF THE RELATIONSHIP BETWEEN THE CONCENTRATIONS OF IRON, TRANSFERRIN AND FERRITIN IN BLOOD SERUM
Introduction. Assessment of the status of iron at the individual and population level is an urgent task. However, the interpretation of the results is associated with a number of difficulties. The inflammatory process, disorders of carbohydrate metabolism and …
CHANGES IN RETINAL VASCULAR STRUCTURE AND BLOOD BIOCHEMICAL MARKERS OF MODELED WHITE RATS IN SHORT-TERM ARTERIAL HYPERTENSION
Introduction: Great progress has been made in the treatment of arterial hypertension (AH). However, despite the fact that new technologies have paved the way for practical medicine, the number of deaths and disabilities from diseases of the cardiovascular syst…
POLYPEPTIDE EFFECT ON STIMULATION OF EXPERIMENTAL ANIMALS CELLULAR PROLIFERATION
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation and apoptosis balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of polypeptide compl…
CLINICAL AND MICROSCOPIC ANALYSIS OF CELLULAR-MOLECULAR COMMUNICATIONS IN FOCAL CORTICAL DYSPLASIA IIIс
Cortical dyslamination with neuronal dysmorphism that occurs adjacent to an arteriovenous malformation (AVM) and is accompanied by epilepsy (E) is classified as FCD IIIc. Its etiology and pathogenesis have yet to be determined. Objective: to clarify the cellul…
SYSTEM MATRIX METALLOPROTEINASE/INHIBITORS IN PATHOGENESIS OF INFILTRATIVE PULMONARY TUBERCULOSIS, DEPENDING ON THE RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS STRAINS FOR ANTI TUBERCULOSIS THERAPY
Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…
VDAC1-DEPENDENT MITOCHONDRIAL EFFECTS OF COMPOUNDS CONTAINING THE 4-HYDROXY-3,5-DI-TRETBUTYL PHENYL SUBSTITUENT IN EXPERIMENTAL FOCAL CEREBRAL ISCHAEMIA
Introduction. Ischemic stroke is one of the most common causes of mortality and primary disability. The treatment of ischemic stroke, especially its complications, includes neuroprotective agents among which correctors of mitochondrial dysfunction stand out. A…
TREC AND KREC IN NEWBORNS OF DIFFERENT GESTATIONAL AGE
Introduction. Primary immunodeficiency (PID) is a congenital disorder of the immune system that causes severe, chronic, autoimmune, infectious and oncological diseases with untimely diagnosis and treatment. Given that PIDs often do not have specific clinical m…