Table of contents
ОБЗОРЫ
PROTEINS TIMP-2, IRISIN AND SITUATION WITH HEMOSTASIS, LIPID METABOLISM AND SEX HORMONES IN FEMALE CARDIOVASCULAR PATIENTS
Introduction. The study of the level of the so-called «youth proteins» TIMP-2 and irisin in diseases of the cardiovascular system is not only of theoretical interest, but also of practical importance, as it outlines new ways to treat these diseases. Purpose of…
THE ROLE OF CHROMOSOMAL V(D)J RECOMBINATION OF LYMPHOCYTES IN THE FORMATION OF ANTITUMOR IMMUNITY AND THE EFFECTIVENESS OF IMMUNOTHERAPY
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
MicroRNAs AS BIOMARKERS OF MIOCARDITIS AND DILATING CARDIOMIOPATHY
Introduction. Currently, clinical diagnosis of myocarditis is a difficult task. The diagnosis of the disease is made on the basis of category IV criteria, which include data of electrocardiography, Holter monitoring, echocardiography and MRI, laboratory biomar…
MOLECULAR GENETIC BASIS OF CERVICAL CANCER
Introduction. Cervical cancer is one of the most common cancers of the female reproductive system, killing more than 250,000 women each year. The etiological agent that causes cervical cancer is well known. HPV infection with high oncogenic risk is the cause o…
ANALYSIS OF MODERN CONCEPTS OF NEURODEGENERATIVE PROPERTIES OF DEPRESSION
Introduction. The review is devoted to the analysis of modern concepts of the neurodegenerative properties of depression. Depression is now regarded as the most common mental illness with significant social consequences. The aim of the study is to determine th…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
EXOSOMAL MIRNAS AS POSSIBLE PREDICTORS OF IMMUNE CHECKPOINT INHIBITORS THERAPY RESPONSE IN CLEAR CELL RENAL CELL CARCINOMA
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
THYROIDOGENESIS AND TRACE ELEMENTS: PREDICTOR POSSIBILITIES
Introduction. Trace elements are widely involved in various metabolic processes in humans, including thyroid hormones. Iodine is a part of thyroid hormones, is actively involved in the work of thyroid enzymes, copper, zinc and manganese are included in the com…
ANALYSIS OF THE RELATIONSHIP OF ITGB3, FV, AND FII GENE POLYMORPHISM WITH THE DEVELOPMENT OF DIABETIC FOOT SYNDROME
Introduction. There is a steady increase in the incidence of type 2 diabetes worldwide. One of the most formidable complications of this pathology is the development of diabetic foot syndrome, which is accompanied by up to 50% of cases of high amputations, dis…