Table of contents
ОБЗОРЫ
The role of soluble immune checkpoint molecules in hematologic malignancies (review)
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
Experimental models of lung sarcoidosis
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown origin. The study of its features and the development of new diagnostic and treatment methods are limited by the absence of generally accepted experimental models. The purpose of the revi…
Molecular aspects of pathogenesis of chronic lymphocytic leukemia
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Innovative approaches to genome editing in the treatment of neurodegenerative diseases
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Use of nanotechnology in the creation of targeted drugs for the treatment of oncological diseases
Objective. To analyze current advances in nanotechnology applications for the development of targeted drugs in oncology, including their mechanisms of action and clinical application prospects. Material and methods. A comprehensive analysis of scientific liter…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Molecular mechanisms of the geroprotective action of magnesium hyaluronan in inflamaging human skin fibroblasts
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
Pathomorphological analysis of salinomycin and nanodiamonds efficacy on Lewis lung carcinoma in mice
Relevance. The search for new antitumor drugs and their selective delivery directly to the tumor site is an important task of modern oncology. For these purposes, currently, the use of various nanoparticles as carriers of medicinal substances is of great impor…
The effect of mexidol on the pro- and antioxidant status of blood cells at the stages of anesthesia and in the postoperative period during cystectomy and nephrectomy
Introduction. In clinical experiments with various pathologies leading to the activation of POL, it was found that one of the most important areas of correction of oxidative stress is the use of drugs with the properties of antioxidants and antihypoxants [6, 7…
Genotoxic effect of SARS-CoV-2 on immunocompetent cells
Introduction. In present, the medical community continues to study the impact of coronavirus infection on various organs and systems of the body. Infection with the SARS-CoV-2 virus causes multifaceted pathological processes and, among other things, affects th…