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Molecular Medicine
Found: 24
Atherosclerosis and the installation of stents can be considered as a model of premature aging of the body. These processes are associated with chronic inflammation, oxidative stress, loss of cellular function, and impaired regeneration, which makes them a con…
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
Cellular senescence is a reaction of cells to damage, which consists in a full stop of the cell cycle, changes of the signaling pathways and secretory activity associated with aging. Regardless the inducing factor, cellular aging of different types have a simi…
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
Introduction. The study of intermoleculars interactions can contribute to the development of ideas about the violation of the endothelium,s adhesive function as one of the pathogenetic links in the development of peripheral artery diseases of atherosclerotic e…
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
Due to the discovery of the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the establishment of its role in lipoprotein metabolism, it became possible to deliver new groups of effective drugs for the treatment of dyslipidemia. The main function of P…
Introduction. For the first time in clinical practice, diagnosis of different stages of lipidemia is conducted according to the level of blood lipids, lipoproteinsand catalase activity. This diagnostic approach can detect early stage of lipidemia against the p…
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
Cardiomyopathies are diseases that affect the heart muscle. They are characterized by myocardial dysfunction in the absence or low severity of common cardiovascular diseases, such as coronary atherosclerosis, hypertension, valvular heart diseases. Cardiomyopat…
Micro-RNAs are a group of small non-coding RNA molecules regulating target genes at the post-transcriptional level. Micro-RNAs are involved in the control of many pathophysiological processes, including dyslipidemia, the main risk factor for atherosclerosis. C…
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. Currently in the world there are conducted numerous studies on the search for biomarkers associated with increased risk of coronary heart disease (CHD). The aim of the study. The study of the levels of such inflammatory biomarkers as the tumor ne…
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …