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Molecular Medicine
Found: 46
Introduction. The search of molecular markers for early diagnostics, prognosis, and identification of new objects for molecular-targeted therapy of primary bone tumors remains one of the most important tasks despite the significant achievements in the treatmen…
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
Introduction. A lot of factors of innate and specific immunity are involved in development of the autoimmune diseases – multiple sclerosis (MS) that cause the damages of myelin envelopes of nerve fibres with irreversible neurological consequences. To decrease …
Background. Plasminogen activators play the leading role in the tumor growth and metastasis. Growth factors stimulate proliferative processes and are involved in neoangiogenesis. Aim of the study. Identification of changes in components of the fibrinolysis sys…
Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
Introduction. Glatiramer acetate (GA, copaxone) – is an immunomodulatory drug, used for reducing the progression of multiple sclerosis. The absence of optimal therapeutic effect in some cases determines the necessity to search the prognostic markers of GA effi…
Introduction. The influence of widespread, often long-lasting infections like herpes simplex virus (HSV), cytomegalovirus (CMV) and chlamydia infections on endocrine profile in organs of reproductive system and the role of infections in pathogenesis of uterine…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
Introduction. The biologic behaviour of the tumor can be determined by both its own characteristics including ploidity of the tumor cells and peculiarities of its lymphocytic and cytokine microenvironment, in particular. The aim of the study. To perform a comp…
Introduction. Insulin-like growth factors (IGF) signaling system plays a major role in the development and progression of various sarcomas and other solid tumors, and therefore its components are regarded as promising diagnostic and prognostic tumor markers an…
Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…
Introduction. The search for criteria for the prediction of the efficacy of targeted therapies will allow not only to optimize the readings, but also to improve the results of treatment of patients with metastatic kidney cancer. The aim of the study is the inv…
Introduction. Amnesic shellfish poisoning is caused by consumption of seafoods contaminated with domoic acid (DA) and is accompanied by gastric colics, nausea, convulsions, hallucinations, loss of orientation and amnesia. As a preventive measure against these …
Introduction. Disorders in anti-TB immunity may be formed at the stage of interaction between antigen-presenting cells and T-lymphocytes by means of cytokines and their receptors. The key cytokines of T-lymphocyte activation are interleukins (IL) of the IL12 f…
Introduction. Skin melanoma is referred to hormone-dependent tumors, the mechanism of influence of endocrine factors on pathogenesis of the tumor, however, has not been determined so far The aim of the study. The studying of the level of steroid hormones, prol…
Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…
Introduction. PI3K/Akt signaling pathway is an important intracellular regulatory mechanism controlling cues of growth factors stimuli, apoptosis, proliferation, and cell motility. Deregulation of activity/expression of PI3K/Akt signaling pathway proteins dete…
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…