Search

Molecular and biological characteristics of tumor cells in testicular embryonal carcinoma explants

Demyashkin G.A., Belokopytov D.V., Shchekin V.I., Borovaya T.G., Rostovskaya V.V., Tsomartova D.A., Pyatigorskaya N.V., Filippova O.V., Maksarova D.D., Mirontsev A.V.

Introduction. Personalized treatment strategies for embryonal carcinoma, a germ cell tumor, are crucial due to the inherent heterogeneity of the tumor. Existing in vitro models inadequately reflect the native tumor microenvironment. Ex vivo organ culture (EVOC…

Molecular mechanisms of the cardiometabolic phenotype in arterial hypertension and obesity in women: from endothelial dysfunction to personalized risk stratification

Khabibulina M.M., Shamilov M.D., Tsurtumiya D.B., Salikova S.P., Fedorets V.N., Sarkisov G.D., Anokhina E.A., Nosevits M., Grebniakova D.A.

Introduction. Arterial hypertension (AH) and obesity form a common cardiometabolic phenotype, in which hemodynamic overload, dysfunctional adipose tissue, estrogen deficiency, dyslipidemia, endothelial dysfunction, vascular remodeling, and electrophysiological…

Transcription factors bioinformatic analysis of differential gene expression in b16 melanoma cells under antitumor alkylating agent application

Lapkina E.Z., Zinchenko I.S., Bondar Е.I., Ruksha T.G.

Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…

Molecular heterogeneity of obesity: psychobiological mechanisms, limitations of the diagnostic model, and prospects for the development of personalized diagnosis and treatment

Grinevich V.B., Zakrevsky V.V., Kravchuk Yu.A., Salikova S.P., Seliverstov P.V., Dikinova K.A., Khupsergenova I.N., Gorbunova D.I., Khabibulina M.M.

Introduction. Obesity can no longer be adequately described by body mass index alone. Similar BMI values may coexist with different fat distribution, inflammatory burden, neuroendocrine dysregulation, psychobehavioral traits, and risks of organ dysfunction. Ob…

THE POSSIBILITIES OF TELEMEDICINE TECHNOLOGIES TO PROVIDE A PERSONALIZED APPROACH IN CARDIOLOGY THROUGH THE USE OF WEARABLE DEVICES

Seliverstov P.V., Salikova S.P., Fedorets V.N., Kutsenko V.P., Shevyakov A.A., Samarskiy I.A., Levitskiy N.M., Akhmad K.A.

Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…

Digital twin of early immunometabolic response after tick bite. LC-MS/MS profiling of lipid mediators and the kynurenine pathway in a QSP model of systemic inflammation

Kutsenko V.P., Nosov A.V., Ushal I.E., Seliverstov P.V., Papina E.I., Chopalaeva A.G., Nuritdinova A.F., Isupov I.I.

Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …

YEAST RNA AS A SOURCE OF IMMUNOMODULATORY NUCLEOTIDES: FROM BIOCHEMISTRY TO CLINICAL APPLICATION

Potupchik T.V., Alikin Yu.S., Generalov S.V., Ermolaev V.V., Kudlay D.A., Ksanaeva J.A., Banar L.S., Makhova A.A.

Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…

FEATURES OF SHIFTS IN THE INDICATORS OF IMMUNE-ANTIOXIDANT STATUS IN RESIDENTS OF THE KRASNODAR TERRITORY SUFFERING FROM POLLINOSIS

Pavlyuchenko I.I., Klimenko Y.V., Golantsev A.S., Kokov E.A., Solomko A.A

Background. Pollinosis is a progressive allergic disease mediated by an IgE-dependent reaction associated with the activation of inflammatory processes, oxidative stress and lipid peroxidation, which affects, first of all, the membrane structures of various ce…

Differences in the genetic landscape of primary gastric adenocarcinoma and its regional lymph node metastases

Ivanov A.A., Avdalyan A.M., Bakarev M.A., Lushnikova E.L., Rumyantseva M.B.

Introduction. Lymphogenous metastasis is a key stage in the progression of gastric cancer. The practice of personalized treatment has historically been based on histological and molecular analysis of the primary tumor, while the molecular-genetic landscape of …

THE INVOLVEMENT OF GLUTAMATE AMPA RECEPTORS IN THE REGULATION OF T-CELL ADHESION IN MULTIPLE SCLEROSIS

Tukhvatullin A.V., Kuzmina U.S., Bakhtiyarova K.Z., Vakhitova Yu.V.

Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…

Molecular patterns of RNA pathogens and immune response to exogenous RNA: recognition mechanisms and therapeutic potential

Potupchik T.V., Alikin Yu.S., Generalov S.V., Ermolaev V.V., Pluzhnikova A.V., Ferzilaeva N.R., Kozarenko M.A.

Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…

Asprosin and meteorin-like peptide: new markers and potential targets in childhood obesity

Kovarenko M.V., Samoilova Yu.G., Podchinenova D.V., Oleynik O.A., Matveeva M.V., Kudlay D.A.

Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…

Telemedicine screening and three-year follow-up of stress-associated autonomic dysfunction in students during university adaptation: clinical and digital risk stratification and personalized prevention

Seliverstov P.V., Salikova S.P., Aleshko O.V., Simakhodsky A.S., Shapovalov V.V., Dyakov T.S., Romakh D.V., Roslyakova M.A., Chernyakova V.E., Golikova D.A.

Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…

Selenium: biochemical role and the importance of balance in the human body

Deeva T.A., Tyagunov E.G., Zolnikova O.Yu.

The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…

A study of the transformation of digital twins into personalized medicine

Seliverstov P.V., Kryukov Е.V., Grinevich V.B., Ivchenko E.V., Minakov E.P.

Introduction. To date, digital twins are the most promising area for the development of modern healthcare. With their help, it is possible to radically change approaches to the diagnosis, treatment and prevention of diseases. In medicine, the concept of digita…

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Potupchik T.V., Alikin Yu.S., Generalov S.V., Evert L.S., Tymchuk V.I., Khalakoeva D.A., Abdullaeva S.R., Spitsyn А.А

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

Blood exosomes of patients with malignant neoplasms of bones and articular cartilage: connection with tumor progression and practical value in clinical medicine

Olgin O.E., Zheravin A.A., Aliev M.D., Choynzonov E.L., Chernyshova A.L., Tamkovich S.N.

Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…

Quantitative indicators of TREC and KREC as predictors of the severity of acute respiratory infections in children

Ligskaya E.V., Eremeeva A.V., Kudlay D.A., Satyshev O.V., Gordukova M.A., Korsunsky A.A.

Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…

Levels of GFAP, Iba1, TNF-α, and caspase-3 in the cingulate cerebral cortex of mice after intraperitoneal lipopolysaccharide

Venediktov A.A., Kuzmin E.A., Pokidova K.S., Oganesyan D.M., Stepanian A.T., Boronikhina T.V., Piavchenko G.A., Kuznetsov S.L.

Introduction. Bacterial lipopolysaccharide (LPS) affects the structure and function of nervous tissue cells. The aim of the study: to explore the impact of intraperitoneal LPS given to mice on levels of such markers as glial fibrillar acidic protein (GFAP), ad…

Serotonin as a modulator of neurogenesis processes in post-traumatic stress disorder

The purpose of this review is to discuss the role of serotonin in the processes of neurogenesis in the hippocampus in post-traumatic stress disorder. Full-text materials were searched in Medline (PubMed) and Scopus databases over the past 15 years. Results. Co…